What they do:
A platform to make artificial viruses as cancer therapeutics.
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HQ: New York, NY, United States
Top Deep Tech Startups in the United States
This list has 1,386 startups and was last updated on Oct 15, 2026. 306 of them are hiring right now. Biggest hubs: San Francisco (704), New York (137), and Los Angeles (79). Largest teams: DoorDash, EquipmentShare, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
1,386 startupsPage 15 of 39
What they do:
Search and automation for engineer-to-order companies
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HQ: San Francisco, CA, United States
What they do:
Making 'REAL' Cow and Human Milk!
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HQ: Boston, MA, United States
What they do:
Your biopharma team, from molecule design to portfolio strategy
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HQ: San Francisco, CA, United States
What they do:
Hypersonic space plane that can take-off from any location and weather
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HQ: Dayton, OH, United States
What they do:
Empowering every doctor and every patient to participate in research
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HQ: New York, NY, United States
Automat
Hiring
What they do:
Agentic automation that understands context, recovers, and improves.
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HQ: San Francisco, CA, United States
YC W23Growth stage
What they do:
Gen-AI Designed Enzymes for Pharmaceutical Innovation
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HQ: Boston, MA, United States
What they do:
AI for ASIC Design Verification
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HQ: San Francisco, CA, United States
What they do:
Farm Genetics Made Easy - Using DNA and Software
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HQ: Asheville, NC, United States
What they do:
Unified flight software and hardware for the mission of tomorrow
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HQ: San Francisco, CA, United States
What they do:
Aggregating Spot Freight Opportunities for Carriers
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HQ: Seattle, WA, United States
What they do:
Starbucks app for restaurants
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HQ: San Francisco, CA, United States
What they do:
Gen AI molecular simulations that reproduce wetlab results
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HQ: San Francisco, CA, United States
What they do:
Automating airport baggage handling with robots.
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HQ: San Francisco, CA, United States
YC S24Early stage
Partcl
Hiring
What they do:
Design a chip in minutes
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HQ: San Francisco, CA, United States
YC X25Early stage
What they do:
Voice AI teams for medicare agencies.
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HQ: San Francisco, CA, United States
What they do:
A Roomba for weeds on a farm.
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HQ: Seattle, WA, United States
What they do:
AI-powered robotics for scientific lab automation.
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HQ: San Francisco, CA, United States
What they do:
chrt is a logistics platform for time-critical shipping
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HQ: Los Angeles, CA, United States
IronLedger.ai
Hiring
What they do:
AI-enabled Corporate Cards and Invoice Processing for Real Estate
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HQ: New York, NY, United States
YC S25Early stage
Relling
Hiring
What they do:
deploying the first billion robots for manufacturing
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
The GD&T Analysis Platform for Engineering Drawings
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HQ: San Francisco, CA, United States
Juxta
Hiring
What they do:
Building a GPS alternative 100x more powerful with no hardware needed.
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
Manipulate Anything Robot
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HQ: San Francisco, CA, United States
What they do:
A new kind of camera that can see through walls.
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HQ: San Francisco, CA, United States
What they do:
Agents that run short-term rental operations end-to-end
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HQ: San Francisco, CA, United States
What they do:
The first wearable that reads your emotions to enhance your EQ.
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HQ: San Francisco, CA, United States
What they do:
Autonomous Customer Operations
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HQ: San Francisco, CA, United States
What they do:
The AI-native trading company: factory prices, delivered, one number
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HQ: San Francisco, CA, United States
What they do:
The AI BPO for financial servies, run by computer-use agents
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HQ: San Francisco, CA, United States
What they do:
The company brain for construction companies
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HQ: San Francisco, CA, United States
What they do:
Supply chain compliance and cost savings
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HQ: Salt Lake City, UT, United States
What they do:
The most capable American-made humanoid robot for $1,688
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HQ: San Francisco, CA, United States
What they do:
Metal manufacturing, faster, cheaper, and more versatile.
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HQ: Boston, MA, United States
Operon
Hiring
What they do:
Agentic data layer for manufacturing & process industries.
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HQ: San Francisco, CA, United States
YC S26Early stage