What they do:
Building the first sensor enabled marketplace for repeat purchases
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HQ: Seattle, WA, United States
Top Deep Tech Startups in the United States
This list has 1,386 startups and was last updated on Oct 15, 2026. 306 of them are hiring right now. Biggest hubs: San Francisco (704), New York (137), and Los Angeles (79). Largest teams: DoorDash, EquipmentShare, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
1,386 startupsPage 19 of 39
What they do:
We put farms inside restaurants, so customers get healthier food and…
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HQ: San Francisco, CA, United States
What they do:
The Self-Hosting Company
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HQ: San Francisco, CA, United States
What they do:
Menten AI designs peptide and protein therapeutics using quantum…
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HQ: San Francisco, CA, United States
What they do:
Bioengineered kidneys for patients with kidney failure
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HQ: San Diego, CA, United States
What they do:
The highest-accuracy global weather data from low-cost flat satellites
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HQ: Orem, UT, United States
What they do:
Neurostimulation implant to restore hearing & speech understanding
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HQ: San Francisco, CA, United States
What they do:
Build factory ready tech packs in minutes.
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HQ: Los Angeles, CA, United States
What they do:
Automated phone ordering system for restaurants
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HQ: San Francisco, CA, United States
What they do:
Growing seaweed to stabilize the climate.
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HQ: San Francisco, CA, United States
What they do:
Smarter Spending for Vacation Property Managers
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HQ: New York, NY, United States
What they do:
Single source of truth for your clinic's finances and supply chain.
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HQ: San Francisco, CA, United States
What they do:
Automating nutrition tracking.
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HQ: San Francisco, CA, United States
What they do:
Building a frontier world model for power
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HQ: Los Angeles, CA, United States
What they do:
Genetically engineering plants for disease resistance.
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HQ: San Francisco, CA, United States
What they do:
AI agents to enroll providers with payors
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HQ: San Francisco, CA, United States
What they do:
AI agent for construction drawings review
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HQ: San Francisco, CA, United States
What they do:
Building low-cost cruise missiles
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HQ: Los Angeles, CA, United States
What they do:
Platform for cities to optimize transit
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HQ: New York, NY, United States
What they do:
Converting biology into digital molecular maps
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HQ: Philadelphia, PA, United States
What they do:
Datadog for robots
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HQ: San Francisco, CA, United States
What they do:
Robotic Training Data at Scale
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HQ: Boston, MA, United States
What they do:
Propaya is an AI-powered commercial real estate intelligence platform that transforms leases and property documents into structured, actionable data. It…
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HQ: San Francisco, CA, United States
What they do:
Autonomous intake and RCM for specialty clinics.
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HQ: San Francisco, CA, United States
What they do:
Making procurement easy
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HQ: San Francisco, CA, United States
What they do:
Build full-stack applications for business operations with AI
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HQ: New York, NY, United States
What they do:
Your AI scheduling assistant for construction
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HQ: San Francisco, CA, United States
What they do:
Quick-turn bent tube shop for aerospace, energy, industrials
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HQ: Los Angeles, CA, United States
What they do:
AI-native remote operations center for hardware fleets
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HQ: San Francisco, CA, United States
What they do:
AI personal assistant for in-home sales
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HQ: San Francisco, CA, United States
What they do:
AI Compliance for Affordable Housing
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HQ: New York, NY, United States
What they do:
AI co-pilot for building plan review and building code compliance
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HQ: Salt Lake City, UT, United States
What they do:
Robots for the inspection and maintenance of data centers
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HQ: Boston, MA, United States
What they do:
Life sciences reagents and software
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HQ: Boston, MA, United States
What they do:
Valuemate automates real estate appraisals with AI
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HQ: New York, NY, United States
What they do:
All-In-One AI Growth Partner. Built for Trades.
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HQ: San Francisco, CA, United States