What they do:
The new American reinsurance company.
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HQ: San Francisco, CA, United States
Top Deep Tech Startups in the United States
This list has 1,386 startups and was last updated on Oct 15, 2026. 306 of them are hiring right now. Biggest hubs: San Francisco (704), New York (137), and Los Angeles (79). Largest teams: DoorDash, EquipmentShare, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
1,386 startupsPage 18 of 39
What they do:
Stripe for telephony
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HQ: Lehi, UT, United States
What they do:
Robots that repair roads
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HQ: San Francisco, CA, United States
What they do:
We assemble PCBs in under 48 hours for quantities under 10
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HQ: San Francisco, CA, United States
What they do:
Open-source semi-humanoid dev kit → home data → autonomy → 20h/wk
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HQ: Los Angeles, CA, United States
What they do:
AI infrastructure for biosecurity
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HQ: New York, NY, United States
What they do:
AI for the physical world
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HQ: San Francisco, CA, United States
What they do:
Truckload Planning at Machine Precision
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HQ: San Francisco, CA, United States
What they do:
AI-native real estate services firm
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HQ: Los Angeles, CA, United States
What they do:
AI-native software for managing rail and bulk operations.
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HQ: Olathe, KS, United States
What they do:
Digital transformation for real economy businesses
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HQ: San Francisco, CA, United States
What they do:
The AI equipment manager for post-acute care
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HQ: New York, NY, United States
What they do:
Large-scale real-world robot & human data for embodied AI
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HQ: San Francisco, CA, United States
What they do:
Machine intelligence for American Welding
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HQ: Los Angeles, CA, United States
What they do:
Vanta for hardware
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HQ: San Francisco, CA, United States
What they do:
Autonomous operations for industrial distributors
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HQ: San Francisco, CA, United States
What they do:
Building the Data Infrastructure layer for Physical AI.
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HQ: San Francisco, CA, United States
What they do:
AI-native pharma company
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HQ: San Francisco, CA, United States
What they do:
USA-made magnetics for robotics and defense.
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HQ: Boston, MA, United States
What they do:
The market behind AI hardware.
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HQ: San Francisco, CA, United States
What they do:
Building a neutral, sovereign alternative to Starlink
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HQ: San Francisco, CA, United States
What they do:
Making chemicals 100,000x faster
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HQ: San Francisco, CA, United States
What they do:
Reliable infrastructure to build, deploy and manage real-world robots.
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HQ: Denver, CO, United States
What they do:
AI-native test infrastructure layer for hardware companies
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HQ: San Francisco, CA, United States
What they do:
Turns real businesses into robotics data vendors
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HQ: San Francisco, CA, United States
What they do:
Evals for robots
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HQ: San Francisco, CA, United States
What they do:
Predictive maintenance for power infrastructure.
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HQ: Baltimore, MD, United States
What they do:
An AI-operated logistics company.
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HQ: San Francisco, CA, United States
What they do:
Embodied Scientific Intelligence
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HQ: San Francisco, CA, United States
What they do:
An AI bracelet that remembers your day and acts before you ask.
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HQ: San Francisco, CA, United States
What they do:
Motor cortex for physical AI
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HQ: San Francisco, CA, United States
What they do:
100% automated inspection for consumer electronics parts
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HQ: San Francisco, CA, United States
What they do:
Kill the drone, keep the jet. Reusable unmanned interceptors.
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HQ: Denver, CO, United States
What they do:
Online circuit simulator and electronic schematic editor.
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HQ: San Francisco, CA, United States
What they do:
Fastest, easiest, and most affordable way for small business owners…
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HQ: San Francisco, CA, United States
What they do:
Synkrino's AI, SATIS is a powerful, unbiased discovery system for…
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HQ: San Francisco, CA, United States