What they do:
The fully autonomous intelligence layer in the sky.
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HQ: Boston, MA, United States
Top Deep Tech Startups in the United States
This list has 1,386 startups and was last updated on Oct 15, 2026. 306 of them are hiring right now. Biggest hubs: San Francisco (704), New York (137), and Los Angeles (79). Largest teams: DoorDash, EquipmentShare, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
1,386 startupsPage 21 of 39
What they do:
Deployment infrastructure for Physical AI
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HQ: San Francisco, CA, United States
What they do:
AI Native Sourcing Broker For Overseas Manufacturing
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HQ: San Francisco, CA, United States
What they do:
The Intelligence layer for Drug Manufacturing
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HQ: Boston, MA, United States
What they do:
Robots for vehicle maintenance.
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HQ: San Francisco, CA, United States
What they do:
AI agent platform for home services companies.
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HQ: San Francisco, CA, United States
What they do:
AI For The Skilled Workforce
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HQ: San Francisco, CA, United States
What they do:
Your personal context, securely portable across every AI app.
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HQ: San Francisco, CA, United States
What they do:
Making Diamond Semiconductors
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HQ: San Francisco, CA, United States
What they do:
Real-world RL environments for robotics models
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HQ: San Francisco, CA, United States
What they do:
Simulating Agents Running Industrial Companies
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HQ: San Francisco, CA, United States
What they do:
Making Defense Manufacturing Faster and Cheaper
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HQ: New York, NY, United States
What they do:
AI-native OS for Real Estate Brokerages
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HQ: San Francisco, CA, United States
What they do:
OpenClaw for manufacturers
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HQ: San Francisco, CA, United States
What they do:
We are a multi-strategy trading firm that trains AI traders.
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HQ: San Francisco, CA, United States
What they do:
Drop-in robotic labor that works on Day 1
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HQ: Los Angeles, CA, United States
What they do:
AI-powered freight brokerage. Quote, book, and track loads in seconds.
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HQ: San Francisco, CA, United States
What they do:
AI-native freight brokerage
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HQ: San Francisco, CA, United States
What they do:
AI for Construction's Back Office
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HQ: San Francisco, CA, United States
What they do:
AI Operating System for Wholesale Distribution
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HQ: San Francisco, CA, United States
What they do:
Legora for AEC (Architecture, Engineering, & Construction) firms
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HQ: San Francisco, CA, United States
What they do:
AI-Native Insurance for Frontier Tech
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HQ: San Francisco, CA, United States
What they do:
Industrial Controllers built for AI
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HQ: Los Angeles, CA, United States
What they do:
AI native platform for real estate closings
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HQ: San Francisco, CA, United States
What they do:
Virtual Reality for Training Robots
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HQ: San Francisco, CA, United States
What they do:
AI-Native Engineering Firm designing Data Centers
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HQ: San Francisco, CA, United States
What they do:
Curing cancer. Starting with dogs.
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HQ: San Francisco, CA, United States
What they do:
The AI Operating System for Auto Shops.
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HQ: San Francisco, CA, United States
What they do:
AI Brokers for Industrial Trade
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HQ: San Francisco, CA, United States
What they do:
Robots that learn on the job
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HQ: San Francisco, CA, United States
What they do:
Foundational infrastructure for Physical AI
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HQ: San Francisco, CA, United States
What they do:
We make silicon on the Moon, to power everything in space.
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HQ: Los Angeles, CA, United States
What they do:
Autonomous rovers to make the ‘Google Maps’ of underground utilities
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HQ: San Francisco, CA, United States
What they do:
Automatic Diagnosis & Fix for Industrial Automation Cells
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HQ: San Francisco, CA, United States
What they do:
Deploying robots to replace workers in hazardous spaces
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HQ: San Francisco, CA, United States
What they do:
AI tools for the chips your AI runs on
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HQ: San Francisco, CA, United States