What they do:
Floating nuclear powered data centers at sea.
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HQ: San Francisco, CA, United States
Top Deep Tech Startups in the United States
This list has 1,386 startups and was last updated on Oct 15, 2026. 306 of them are hiring right now. Biggest hubs: San Francisco (704), New York (137), and Los Angeles (79). Largest teams: DoorDash, EquipmentShare, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
1,386 startupsPage 22 of 39
What they do:
World's Earliest Test for Alzheimer's Biomarkers
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HQ: San Francisco, CA, United States
What they do:
Agents running industrial enterprises from back office to shop floor
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HQ: San Francisco, CA, United States
What they do:
AI for the industries that power America.
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HQ: San Francisco, CA, United States
What they do:
Quick-turn, purpose-built motors & actuators for all
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HQ: Los Angeles, CA, United States
What they do:
A consumer brain-computer interface you can map to anything.
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HQ: San Francisco, CA, United States
What they do:
The generalist robot deployment company.
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HQ: San Francisco, CA, United States
What they do:
Precision navigation for UAVs operating without GPS.
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HQ: San Francisco, CA, United States
What they do:
On Demand CNC Prototyping
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HQ: San Francisco, CA, United States
What they do:
A foundation model for engineering physics
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HQ: San Francisco, CA, United States
What they do:
voice-first hardware interface for human-agent interaction
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HQ: San Francisco, CA, United States
What they do:
The AI decision engine for factories, warehouses and fleets
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HQ: San Francisco, CA, United States
What they do:
Accelerating scaled plastics with additive technologies
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HQ: El Segundo, CA, United States
What they do:
a phone where AI is the interface
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HQ: San Francisco, CA, United States
What they do:
Like Crosby, but for real estate development
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HQ: Phoenix, AZ, United States
What they do:
Lark - AI agents that automate workflows for wholesale distributors
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HQ: San Francisco, CA, United States
What they do:
The pit crew for machines and robots.
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HQ: San Francisco, CA, United States
What they do:
The operating system for commercial buildings.
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HQ: Niagara Falls, NY, United States
What they do:
Perlara: building the YC for rare disease parents
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HQ: San Francisco, CA, United States
What they do:
Prime Lightworks Inc. manufactures electric propulsion systems for…
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HQ: Culver City, CA, United States
What they do:
Universal, Pure-GPU HTML Renderer
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HQ: San Francisco, CA, United States
What they do:
Multi-agent AI for physical logistics operations
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HQ: San Francisco, CA, United States
What they do:
Pelvic floor fitness made easy
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HQ: Chicago, IL, United States
What they do:
Redefining the Standard of Care for Iron Deficiency Anemia
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HQ: San Francisco, CA, United States
What they do:
Faster processors for solving NP-complete problems
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HQ: San Diego, CA, United States
What they do:
Specialized agents for real work
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HQ: Los Angeles, CA, United States
What they do:
Building and Protecting an Exciting Future
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HQ: Los Angeles, CA, United States
What they do:
Turning messy inboxes into ERP-Ready Data
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HQ: San Francisco, CA, United States
What they do:
Power-ready land for AI data centers
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HQ: New York, NY, United States
What they do:
AI agents for global trade compliance
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HQ: San Francisco, CA, United States
What they do:
AI for the physical world
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HQ: Los Angeles, CA, United States
What they do:
Infrastructure Cartography
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HQ: Boston, MA, United States
What they do:
A robotics intelligence system for metal fabrication
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HQ: San Francisco, CA, United States
What they do:
Accelerated Physics Kernels for Computational Engineering
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HQ: San Francisco, CA, United States
What they do:
US-Made Parts for Robots
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HQ: Austin, TX, United States
What they do:
AI-native, hardware procurement marketplace
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HQ: San Francisco, CA, United States