What they do:
Rest is an AI sleep coach that helps you fix your sleep for good,…
Quick facts:
HQ: San Francisco, CA, United States
Top Digital Health Startups in California
This list has 210 startups and was last updated on Oct 15, 2026. 61 of them are hiring right now. Biggest hubs: San Francisco (190), Los Angeles (12), and San Diego (2). Largest teams: Truepill, Clipboard, and Athelas. Latest round: Malama Health raised $5.32M (Feb 26, 2026).
210 startupsPage 2 of 6
Probably Genetic
Hiring
What they do:
Patient Intelligence Platform for Genetic Disease
Quick facts:
HQ: San Francisco, CA, United States
Arini
Hiring
What they do:
The single platform to run all healthcare operations
Quick facts:
HQ: San Francisco, CA, United States
What they do:
“One Medical for pets.”
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI-generated personalized nutrition solutions, built for you daily.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Brain Longevity
Quick facts:
HQ: San Francisco, CA, United States
What they do:
The first digital mental health system for youth
Quick facts:
HQ: San Francisco, CA, United States
Lamar Health
Hiring
What they do:
Take Care of Shitty Paperwork for Expensive Drugs
Quick facts:
HQ: San Francisco, CA, United States
Toothy AI
Hiring
What they do:
AI for insurance verification & billing at dental clinics
Quick facts:
HQ: San Francisco, CA, United States
Sunflower
Hiring
What they do:
We are building an AI-native telemedicine clinic for addiction. 🌻
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Predicting and preventing heart disease.
Quick facts:
HQ: San Francisco, CA, United States
Brighterway
Hiring
What they do:
Streamlining the medical record review process in workers comp
Quick facts:
HQ: San Francisco, CA, United States
What they do:
MedCrypt gives medical device vendors cybersecurity features in a few…
Quick facts:
HQ: San Diego, CA, United States
Legion Health
Hiring
What they do:
Autonomous medical care
Quick facts:
HQ: San Francisco, CA, United States
What they do:
24/7 pediatric clinic in every family's living room
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Automating Healthcare Revenue Cycle Management with AI Workforce
Quick facts:
HQ: San Francisco, CA, United States
Syntra
Hiring
What they do:
Faster healthcare payments
Quick facts:
HQ: San Francisco, CA, United States
What they do:
FidoCure® is the leader in Precision Medicine for Canine Oncology.
Quick facts:
HQ: San Francisco, CA, United States
Vena Vitals
Hiring
What they do:
A small sticker that monitors blood pressure continuously
Quick facts:
HQ: Irvine, CA, United States
SafeBeat
Hiring
What they do:
First ECG AI to go beyond diagnostics and recommend treatment
Quick facts:
HQ: San Francisco, CA, United States
Shimmer
Hiring
What they do:
1:1 ADHD coaching, 5-10X More affordable than alternatives
Quick facts:
HQ: San Francisco, CA, United States
Careforce
Hiring
What they do:
AI Workers for Healthcare Orgs to Find, Call & Schedule More Patients.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Longevity for the 99%.
Quick facts:
HQ: San Francisco, CA, United States
Clicks Health
Hiring
What they do:
AI agents for your healthcare back-office operations.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
API for healthcare compliance
Quick facts:
HQ: San Francisco, CA, United States
What they do:
The smart testing platform that unlocks digital health at home.
Quick facts:
HQ: San Francisco, CA, United States
Sonia
Hiring
What they do:
Validated mental health support in your pocket, anytime.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
We are making a HIPAA-compliant, Groupme app for doctors to…
Quick facts:
HQ: Los Gatos, CA, United States
What they do:
The Human Diagnosis Project.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
The free HIV vaccine.
Quick facts:
HQ: San Francisco, CA, United States
Rinse
Hiring
What they do:
We're building the One Medical for dental
Quick facts:
HQ: San Francisco, CA, United States
Cair Health
Hiring
What they do:
AI Agents for Healthcare RCM
Quick facts:
HQ: San Francisco, CA, United States
Dodo
Hiring
What they do:
AI agents that handle communications for clinics
Quick facts:
HQ: San Francisco, CA, United States
Vera Health
Hiring
What they do:
AI-powered clinical decision support for healthcare providers
Quick facts:
HQ: San Francisco, CA, United States
Asteroid
Hiring
What they do:
The integration layer for healthcare: EHRs, payer portals & more
Quick facts:
HQ: San Francisco, CA, United States
Novoflow
Hiring
What they do:
Computer-using agents for healthcare operations
Quick facts:
HQ: San Francisco, CA, United States