What they do:
A social app for phone calls. Express yourself and make real friends.
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HQ: San Francisco, CA, United States
Top Digital Health Startups in California
This list has 210 startups and was last updated on Oct 15, 2026. 61 of them are hiring right now. Biggest hubs: San Francisco (190), Los Angeles (12), and San Diego (2). Largest teams: Truepill, Clipboard, and Athelas. Latest round: Malama Health raised $5.32M (Feb 26, 2026).
210 startupsPage 3 of 6
What they do:
Pediatric digital therapeutic for the +100M families in the US
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HQ: San Francisco, CA, United States
What they do:
Self-learning care for complex illness
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HQ: San Francisco, CA, United States
What they do:
The API for Diagnostic Test Analysis (COVID-19, FLU, RSV, STD,…
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HQ: Los Angeles, CA, United States
Shasta Health
Hiring
What they do:
Helping rehab practices book more patients
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HQ: San Francisco, CA, United States
Andy AI
Hiring
What they do:
Faster clinical documentation for home health nurses
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HQ: San Francisco, CA, United States
Adentris
Hiring
What they do:
Real-time AI Compliance & Revenue Integrity for Medical Providers
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HQ: San Francisco, CA, United States
Janeen
Hiring
What they do:
Prior auths and benefits investigation for infusion clinics
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HQ: San Francisco, CA, United States
Health Harbor
Hiring
What they do:
Using generative AI to call insurance for healthcare clinics
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HQ: San Francisco, CA, United States
What they do:
One clinic for every sleep issue
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HQ: San Francisco, CA, United States
What they do:
Early detection of Alzheimer's disease
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HQ: San Francisco, CA, United States
What they do:
AI workers that book, scribe, code, interpret, and answer clinicians
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HQ: San Francisco, CA, United States
What they do:
Portable cryoablation to prevent cervical cancer
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HQ: San Francisco, CA, United States
Reviving Mind
Hiring
What they do:
Addressing Loneliness and Isolation for Seniors
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HQ: San Francisco, CA, United States
Quill Bills
Hiring
What they do:
AI-Powered Medical Billing
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HQ: San Francisco, CA, United States
Klarify
Hiring
What they do:
AI Agent for Therapists
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HQ: San Francisco, CA, United States
Allia Health
Hiring
What they do:
AI-Native Medical Group for Mental Health
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HQ: San Francisco, CA, United States
What they do:
Group-Therapy Platform for Providers and Health Systems
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HQ: San Francisco, CA, United States
Delfino AI
Hiring
What they do:
Generative AI for administrative automation in healthcare
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HQ: San Francisco, CA, United States
Layers
Hiring
What they do:
Improve your appearance by measuring, understanding, and tracking…
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HQ: San Francisco, CA, United States
Taiga
Hiring
What they do:
Autonomous medical billing
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HQ: San Francisco, CA, United States
What they do:
At-home oral health testing, coaching & care
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HQ: San Francisco, CA, United States
What they do:
Scheduling software for digital health clinics to do more with less.
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HQ: San Francisco, CA, United States
What they do:
AI workforce management for healthcare
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HQ: San Francisco, CA, United States
What they do:
A research lab for one
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HQ: San Francisco, CA, United States
What they do:
The AI operating system for radiology networks
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HQ: San Francisco, CA, United States
What they do:
The lifestyle medicine layer for clinicians.
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HQ: San Francisco, CA, United States
What they do:
Entvin is building AI agents specifically designed to support regulatory teams in the life sciences industry. Our platform leverages AI to streamline…
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HQ: San Francisco, CA, United States
Knowtex
Hiring
What they do:
Making doctors 2x more efficient with AI note-taking & charge capture
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HQ: San Francisco, CA, United States
What they do:
Unifying how the optical industry does business.
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HQ: Los Angeles, CA, United States
What they do:
At-cost preventive health: Labs, Scans, Genetics, Supplements and Rx
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HQ: San Francisco, CA, United States
What they do:
Helping hospitals identify and prevent avoidable harm using AI
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HQ: San Francisco, CA, United States
What they do:
AI agents for risk-bearing healthcare organizations
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HQ: San Francisco, CA, United States
What they do:
Adaptive training coach for runners, cyclists, and triathletes
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HQ: San Francisco, CA, United States
Plena Health
Hiring
What they do:
Plena is the AI operating system for specialty medical practices
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HQ: San Francisco, CA, United States
YC X26Early stage
What they do:
Full Stack Pharmaceutical Company for Personalized Peptides and GLP-1s
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HQ: San Francisco, CA, United States