Variance
Hiring
What they do:
AI Agents for Fraud Review and Investigations
Quick facts:
HQ: San Francisco, CA, United States
Top AI & Data Startups in California
This list has 1,550 startups and was last updated on Oct 15, 2026. 481 of them are hiring right now. Biggest hubs: San Francisco (1,471), Los Angeles (51), and San Diego (5). Largest teams: Cruise, Relativity Space, and Fivetran. Latest round: Safi Analytics raised $22.4M (Oct 14, 2026).
1,550 startupsPage 7 of 44
Andromeda Surgical
Hiring
What they do:
Autonomous surgical robots
Quick facts:
HQ: San Francisco, CA, United States
RetailReady
Hiring
What they do:
An AI-powered supply chain compliance engine
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HQ: San Francisco, CA, United States
Unsloth AI
Hiring
What they do:
Open-Source Reinforcement Learning (RL) & Fine-tuning for LLMs.
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HQ: San Francisco, CA, United States
Intryc
Hiring
What they do:
Intryc is the unified quality assurance, governance, and training…
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HQ: San Francisco, CA, United States
Cartage
Hiring
What they do:
Autonomous freight coordination
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HQ: San Francisco, CA, United States
Assembly HOA
Hiring
What they do:
AI-native HOA Management Company
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HQ: San Francisco, CA, United States
Sixtyfour
Hiring
What they do:
Intelligence Infrastructure on People and Entities
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HQ: San Francisco, CA, United States
Ignition Benefits
Hiring
What they do:
The AI-Native Benefits Brokerage
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HQ: Los Angeles, CA, United States
Etleap
Hiring
What they do:
Etleap is an ETL solution for creating perfect data pipelines.
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HQ: San Francisco, CA, United States
What they do:
AI tax filing for complex returns
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HQ: San Francisco, CA, United States
Legion Health
Hiring
What they do:
Autonomous medical care
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HQ: San Francisco, CA, United States
Layerup
Hiring
What they do:
Agentic AI OS for Financial Services and Insurance
Quick facts:
HQ: San Francisco, CA, United States
1stCollab
Hiring
What they do:
Performance-Optimized Influencer Marketing at Scale
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HQ: San Francisco, CA, United States
Skyvern
Hiring
What they do:
Open Source AI Agent to automate browser workflows via an API
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HQ: San Francisco, CA, United States
ParadeDB
Hiring
What they do:
You should just use Postgres.
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HQ: San Francisco, CA, United States
Simple AI
Hiring
What they do:
AI voice that sells
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HQ: San Francisco, CA, United States
Lanesurf
Hiring
What they do:
Book any load in 10 minutes
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HQ: San Francisco, CA, United States
Trelium
Hiring
What they do:
AI Agents for Enterprise Wide Operations
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HQ: San Francisco, CA, United States
What they do:
Olark gives you an AI agent that works your marketing funnel 24/7
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HQ: San Francisco, CA, United States
Flockjay
Hiring
What they do:
AI-driven learning, content, and coaching for sales teams
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HQ: San Francisco, CA, United States
What they do:
Ramen VR is transforming game development with advanced XR + AI tools.
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HQ: San Francisco, CA, United States
What they do:
Using CRISPR to find treatments for cancer and inflammation
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HQ: San Francisco, CA, United States
What they do:
Affogato AI — Your Agent for instant TikToks, Reels, and ads.
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HQ: San Francisco, CA, United States
What they do:
AI SDET for mobile apps
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HQ: San Francisco, CA, United States
Dart
Hiring
What they do:
The work and agent management platform
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HQ: San Francisco, CA, United States
Julius
Hiring
What they do:
Build and analyze things with AI
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HQ: San Francisco, CA, United States
Coris
Hiring
What they do:
AI risk and ops platform for Payment Processors, Banks, SaaS…
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HQ: San Francisco, CA, United States
Rubbrband
Hiring
What they do:
A new kind of creative company.
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HQ: San Francisco, CA, United States
Reflex
Hiring
What they do:
The operating system for building mission-critical enterprise apps.
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HQ: San Francisco, CA, United States
What they do:
Social listening for the video era
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HQ: San Francisco, CA, United States
Magic Patterns
Hiring
What they do:
Go from idea to production with AI.
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HQ: San Francisco, CA, United States
What they do:
Automating Healthcare Revenue Cycle Management with AI Workforce
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HQ: San Francisco, CA, United States
Diffuse Bio
Hiring
What they do:
Generative AI for protein design
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HQ: San Francisco, CA, United States
What they do:
AI Agents For RFP and Questionnaire Response Automation
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HQ: San Francisco, CA, United States
Event Horizon Labs
Hiring
What they do:
AI research lab automating all of investing
Quick facts:
HQ: San Francisco, CA, United States