What they do:
We create activating antibodies to treat diseases others can’t.
Quick facts:
HQ: San Francisco, CA, United States
Top AI Startups in California
This list has 1,429 startups and was last updated on Oct 15, 2026. 461 of them are hiring right now. Biggest hubs: San Francisco (1,355), Los Angeles (47), and San Diego (4). Largest teams: Cruise, Relativity Space, and Athelas. Latest round: Agriculture Scout AI raised $425K (Oct 13, 2026).
1,429 startupsPage 8 of 40
SafeBeat
Hiring
What they do:
First ECG AI to go beyond diagnostics and recommend treatment
Quick facts:
HQ: San Francisco, CA, United States
ego
Hiring
What they do:
AI applied research lab building synthetic sapience; human-like AI
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HQ: San Francisco, CA, United States
ROE
Hiring
What they do:
AI for risk and compliance
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HQ: San Francisco, CA, United States
Centralize
Hiring
What they do:
The relationship intelligence platform for enterprise revenue
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HQ: San Francisco, CA, United States
Raindrop
Hiring
What they do:
Sentry for AI Agents
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HQ: San Francisco, CA, United States
GetCrux
Hiring
What they do:
AI Creative Strategist
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HQ: San Francisco, CA, United States
FirstWork
Hiring
What they do:
Rippling for seasonal workers
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HQ: San Francisco, CA, United States
What they do:
AI Compliance Analysts for Banks & Fintechs
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HQ: San Francisco, CA, United States
Careforce
Hiring
What they do:
AI Workers for Healthcare Orgs to Find, Call & Schedule More Patients.
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HQ: San Francisco, CA, United States
Ergo
Hiring
What they do:
Ergo is the context layer that helps revenue teams close more deals.
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HQ: San Francisco, CA, United States
What they do:
Meet Tara AI, your new engineering efficiency co-pilot.
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HQ: San Francisco, CA, United States
Orangewood Labs
Hiring
What they do:
Orangewood builds amazing robots that people want
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HQ: San Francisco, CA, United States
WarpBuild
Hiring
What they do:
Accelerate software development with WarpBuild's 10x faster CI infra.
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HQ: San Francisco, CA, United States
SilkChart
Hiring
What they do:
AI Sales Assistant to increase playbook adoption and win more deals
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HQ: San Francisco, CA, United States
goodfin
Hiring
What they do:
Building the next generation of wealth
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HQ: Los Angeles, CA, United States
ShortLoop
Hiring
What they do:
Phone AI that Captures Every Dealership Revenue Opportunity
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HQ: San Francisco, CA, United States
Berry
Hiring
What they do:
Scale customer success and onboarding with AI
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HQ: San Francisco, CA, United States
Silimate
Hiring
What they do:
Fast, efficient agents for chip design and debug
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HQ: San Francisco, CA, United States
Pivot Robotics
Hiring
What they do:
AI for Robot Arms in Factories
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HQ: San Francisco, CA, United States
Paradigm
Hiring
What they do:
A reimagined workspace with AI at its core
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HQ: San Francisco, CA, United States
What they do:
AI lipsync tool for video content creators
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HQ: San Francisco, CA, United States
Ocular AI
Hiring
What they do:
Applied AI Data Research Lab Encoding Human Expertise into Machines…
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HQ: San Francisco, CA, United States
Bucket Robotics
Hiring
What they do:
Defect detection for manufacturing built from CAD and synthetic data.
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HQ: San Francisco, CA, United States
Conductor
Hiring
What they do:
Run a team of coding agents on your Mac
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HQ: San Francisco, CA, United States
Nitrode
Hiring
What they do:
Frontier AI research to advance game development
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HQ: San Francisco, CA, United States
Woz
Hiring
What they do:
Claude Code plugin that reduces token consumption and cost by 50%
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HQ: San Francisco, CA, United States
Naïve
Hiring
What they do:
Autonomous Company Infrastructure
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HQ: San Francisco, CA, United States
Dedalus Labs
Hiring
What they do:
Persistent computers for AI agents
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HQ: San Francisco, CA, United States
Hyperspell
Hiring
What they do:
Your Company Brain
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HQ: San Francisco, CA, United States
Aside
Hiring
What they do:
The browser built to do real work for you
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HQ: San Francisco, CA, United States
Clicks Health
Hiring
What they do:
AI agents for your healthcare back-office operations.
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HQ: San Francisco, CA, United States
Origin
Hiring
What they do:
AI and Data for Cancer Therapeutics
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HQ: San Francisco, CA, United States
Piris Labs
Hiring
What they do:
The Networking Layer of AI
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HQ: San Francisco, CA, United States
Shape (ShapeScale)
Hiring
What they do:
ShapeScale is a personal 3D scanner and fitness tracker that…
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HQ: San Francisco, CA, United States
What they do:
Flat-fee patent & trademark counsel with top firm results
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HQ: San Francisco, CA, United States