What they do:
AI that finds value creation opportunities across enterprise…
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HQ: San Francisco, CA, United States
Top B2B Software Startups in California
This list has 2,349 startups and was last updated on Oct 15, 2026. 592 of them are hiring right now. Biggest hubs: San Francisco (2,110), Los Angeles (79), and San Diego (12). Largest teams: Stripe, Deel, and GrubMarket. Latest round: Modal raised $750M (Oct 14, 2026).
2,349 startupsPage 26 of 66
Operon
Hiring
What they do:
Agentic data layer for manufacturing & process industries.
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HQ: San Francisco, CA, United States
YC S26Early stage
Lamb Labs
Hiring
What they do:
Lightning fast chips with hardcoded AI models
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HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
Grok bot for GTM & Revenue teams
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HQ: San Francisco, CA, United States
What they do:
Context layer for enterprise AI surveying employees with voice agents
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HQ: San Francisco, CA, United States
What they do:
We tell sellers exactly when a company is ready to buy.
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HQ: San Francisco, CA, United States
Spine
Hiring
What they do:
We run benefits, payroll & compliance for startups, for free
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HQ: San Francisco, CA, United States
YC F26Early stage
What they do:
A live watermark inside AI voice that survives phone calls
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HQ: San Francisco, CA, United States
What they do:
One-click screen sharing with installation-free viewing on all devices
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HQ: San Francisco, CA, United States
What they do:
Sourcing marketplace for semiconductor fab spare parts.
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HQ: Newport Beach, CA, United States
What they do:
Better, faster tech vendor research
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HQ: Los Angeles, CA, United States
What they do:
AI-Native Restaurant POS
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HQ: San Francisco, CA, United States
What they do:
Sell beyond the store.
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HQ: San Francisco, CA, United States
What they do:
LinkedIn content consultancy and scheduling platform for busy founders
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HQ: San Diego, CA, United States
What they do:
Mobile app and coaching program that helps employees sleep better
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HQ: San Francisco, CA, United States
What they do:
2 sided Marketplace for accelerating medical research
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HQ: San Francisco, CA, United States
What they do:
Classify Anything
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HQ: CA, United States
What they do:
We make it simple for call centers to automate quality assurance.
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HQ: San Francisco, CA, United States
What they do:
AI agents rewriting & optimising your internal documentation for LLMs
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HQ: San Francisco, CA, United States
What they do:
Get your brand discovered and recommended by ChatGPT
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HQ: San Francisco, CA, United States
What they do:
Internal developer platform for Terraform, OpenTofu and Helm
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HQ: Los Angeles, CA, United States
What they do:
Building the definitive all-in-one on-device AI productivity tool
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HQ: Los Angeles, CA, United States
What they do:
Superpowers for litigators
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HQ: San Francisco, CA, United States
What they do:
AI-powered product assistance for modern software teams
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HQ: San Francisco, CA, United States
What they do:
Frontier AI to stop fraud, abuse, and financial crimes.
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HQ: San Francisco, CA, United States
What they do:
Headcount & Compensation Management
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HQ: San Francisco, CA, United States
What they do:
Automating Data Entry for Clinical Trials
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HQ: San Francisco, CA, United States
What they do:
Revenue Superintelligence
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HQ: San Francisco, CA, United States
What they do:
A marketplace for B2B businesses to buy warm intros.
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HQ: San Francisco, CA, United States
What they do:
QA agents that write tests 10x faster with zero maintenance
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HQ: San Francisco, CA, United States
What they do:
Invoicing that pays you even if your buyer doesn’t
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HQ: San Francisco, CA, United States
What they do:
We build floating solar data centers
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HQ: San Francisco, CA, United States
What they do:
Executable healthcare contracts
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HQ: San Francisco, CA, United States
What they do:
AI Employees for Distributors
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HQ: San Francisco, CA, United States
What they do:
The Open Source Agentic Browser
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HQ: San Francisco, CA, United States
What they do:
Reliable AI for Regulated Ops
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HQ: San Francisco, CA, United States