Partcl
Hiring
What they do:
Design a chip in minutes
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HQ: San Francisco, CA, United States
YC X25Early stage
Top B2B Software Startups in California
This list has 2,362 startups and was last updated on Oct 16, 2026. 592 of them are hiring right now. Biggest hubs: San Francisco (2,118), Los Angeles (80), and San Diego (13). Largest teams: Stripe, Deel, and GrubMarket. Latest round: Exploration Technologies, Inc./DE raised $8.3M (Oct 15, 2026).
2,362 startupsPage 25 of 66
What they do:
Voice AI teams for medicare agencies.
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HQ: San Francisco, CA, United States
What they do:
Frontier Data
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HQ: San Francisco, CA, United States
Wildcard
Hiring
What they do:
AEO/GEO for E-Commerce and Retail
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HQ: San Francisco, CA, United States
YC W25Early stage
What they do:
AI native financial institution
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HQ: San Francisco, CA, United States
What they do:
AI-powered robotics for scientific lab automation.
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HQ: San Francisco, CA, United States
What they do:
Encrypted AI with verifiable privacy
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HQ: San Francisco, CA, United States
What they do:
Turn scattered data into one platform for decision-making
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HQ: San Francisco, CA, United States
What they do:
chrt is a logistics platform for time-critical shipping
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HQ: Los Angeles, CA, United States
What they do:
AI agents for risk-bearing healthcare organizations
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HQ: San Francisco, CA, United States
Adaptional
Hiring
What they do:
AI-powered insurance claims review
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
The E2E testing layer for AI-driven development
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HQ: San Francisco, CA, United States
What they do:
Agents that learn your company and work 24/7
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HQ: San Francisco, CA, United States
Proliferate
Hiring
What they do:
Do your life's work with agents
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HQ: San Francisco, CA, United States
YC S25Early stage
Relling
Hiring
What they do:
deploying the first billion robots for manufacturing
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
AI agents for E2E testing across mobile & web
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HQ: San Francisco, CA, United States
What they do:
Airline customer service, fully automated.
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HQ: San Francisco, CA, United States
What they do:
The GD&T Analysis Platform for Engineering Drawings
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HQ: San Francisco, CA, United States
What they do:
Browser infra for AI agents: sessions, auth, proxies, payments
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HQ: San Francisco, CA, United States
Juxta
Hiring
What they do:
Building a GPS alternative 100x more powerful with no hardware needed.
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
AI that creates and runs ads, end-end
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HQ: San Francisco, CA, United States
Soren
Hiring
What they do:
The AI Transformation Company
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HQ: San Francisco, CA, United States
YC F25Early stage
What they do:
API for unlimited, durable, real-time streams
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HQ: San Francisco, CA, United States
What they do:
AI Infra for real-time vision applications
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HQ: San Francisco, CA, United States
VOYGR
Hiring
What they do:
Real-world place intelligence for AI apps and agents
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HQ: San Francisco, CA, United States
YC W26Early stage
Cardinal
Hiring
What they do:
Revenue Agents for GTM teams
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HQ: San Francisco, CA, United States
YC W26Early stage
What they do:
Agents that run short-term rental operations end-to-end
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HQ: San Francisco, CA, United States
What they do:
Real-world sandboxes to test and train AI agents
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HQ: San Francisco, CA, United States
AgentPhone
Hiring
What they do:
Phone Numbers for AI Agents
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HQ: San Francisco, CA, United States
YC X26Early stage
What they do:
Find and engage with desperate buyers across LinkedIn, Email, and X
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HQ: San Francisco, CA, United States
What they do:
Scale AI scientists whose own breakthroughs accelerate the next.
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HQ: San Francisco, CA, United States
What they do:
Automated LiveOps for Game Studios
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HQ: San Francisco, CA, United States
What they do:
Autonomous Customer Operations
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HQ: San Francisco, CA, United States
What they do:
The AI-native trading company: factory prices, delivered, one number
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HQ: San Francisco, CA, United States
What they do:
The AI BPO for financial servies, run by computer-use agents
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HQ: San Francisco, CA, United States
What they do:
Earned intelligence for every company
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HQ: San Francisco, CA, United States