What they do:
Autonomous Customer Operations
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HQ: San Francisco, CA, United States
Top Deep Tech Startups in San Francisco
This list has 705 startups and was last updated on Oct 16, 2026. 180 of them are hiring right now. Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Aikido Technologies raised $1.72M (Oct 8, 2026).
705 startupsPage 9 of 20
What they do:
The AI-native trading company: factory prices, delivered, one number
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HQ: San Francisco, CA, United States
What they do:
The AI BPO for financial servies, run by computer-use agents
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HQ: San Francisco, CA, United States
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The company brain for construction companies
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HQ: San Francisco, CA, United States
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The most capable American-made humanoid robot for $1,688
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HQ: San Francisco, CA, United States
Operon
Hiring
What they do:
Agentic data layer for manufacturing & process industries.
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HQ: San Francisco, CA, United States
YC S26Early stage
Lamb Labs
Hiring
What they do:
Lightning fast chips with hardcoded AI models
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HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
Synvivia applies chemical control over cell behavior
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HQ: San Francisco, CA, United States
What they do:
Smart gels for local drug delivery to the gut
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HQ: San Francisco, CA, United States
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Shiru leverages ML to create proteins to feed the world sustainably.
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HQ: San Francisco, CA, United States
What they do:
AI-Native Restaurant POS
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HQ: San Francisco, CA, United States
What they do:
We make bacteria and plants that clean up pollution.
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HQ: San Francisco, CA, United States
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Make diesel semi trucks hybrid-electric
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HQ: San Francisco, CA, United States
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The spatial AI to plan, build and maintain the world's infrastructure
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HQ: San Francisco, CA, United States
What they do:
Enzyme design models.
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HQ: San Francisco, CA, United States
What they do:
Building a nervous system for the atmosphere
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HQ: San Francisco, CA, United States
What they do:
We build floating solar data centers
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HQ: San Francisco, CA, United States
What they do:
Connect with hotel owners around the world.
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HQ: San Francisco, CA, United States
What they do:
Streamlining Data Capture to Report Creation for Heavy Industries
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HQ: San Francisco, CA, United States
What they do:
Applied research lab for hardware design
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HQ: San Francisco, CA, United States
What they do:
The world's first AI-maximalist pharma company
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HQ: San Francisco, CA, United States
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AI powered brokerage reducing residential rental commissions in NYC…
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HQ: San Francisco, CA, United States
What they do:
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HQ: San Francisco, CA, United States
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AI native real-estate appraisal firm
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HQ: San Francisco, CA, United States
What they do:
Operational Intelligence for Global Logistics
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HQ: San Francisco, CA, United States
What they do:
AI benchmarks that measure general intelligence and inspire new ideas
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HQ: San Francisco, CA, United States
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Robots that run autonomous depots for autonomous fleets.
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HQ: San Francisco, CA, United States
What they do:
Evolutionary intelligence for autoimmune disease
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HQ: San Francisco, CA, United States
What they do:
AI that turns any camera to an autonomous worker with real-time vision
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HQ: San Francisco, CA, United States
What they do:
Annotations for robotics data
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HQ: San Francisco, CA, United States
What they do:
Nervous System for Physical AI
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HQ: San Francisco, CA, United States
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Building drone swarms that hunt hidden enemies.
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HQ: San Francisco, CA, United States
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AI-native procurement services for the physical economy
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HQ: San Francisco, CA, United States
What they do:
Microgrids in a box built anywhere in days
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HQ: San Francisco, CA, United States
What they do:
Automating away manual admin for food distributors: texts to ERP
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HQ: San Francisco, CA, United States
What they do:
Robots for high skilled labor powering AI infrastructure
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HQ: San Francisco, CA, United States