What they do:
Vertically integrated commercial construction
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HQ: San Francisco, CA, United States
Top Deep Tech Startups in San Francisco
This list has 704 startups and was last updated on Oct 15, 2026. 180 of them are hiring right now. Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Aikido Technologies raised $1.72M (Oct 8, 2026).
704 startupsPage 8 of 20
What they do:
We turn CO2 into battery-grade graphite and oxygen.
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HQ: San Francisco, CA, United States
What they do:
The spot market for semiconductors
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HQ: San Francisco, CA, United States
What they do:
We stop cows from burping methane.
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HQ: San Francisco, CA, United States
What they do:
Limitless Real Estate
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HQ: San Francisco, CA, United States
What they do:
Manufacturing more proteins with AI.
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HQ: San Francisco, CA, United States
What they do:
We make robots that move boxes in warehouses
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HQ: San Francisco, CA, United States
Consus
Hiring
What they do:
The fastest and cheapest way to use AI with ITAR or CUI data.
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HQ: San Francisco, CA, United States
What they do:
The memory computer for your digital life.
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HQ: San Francisco, CA, United States
What they do:
The personal AI agent for Korea.
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HQ: San Francisco, CA, United States
What they do:
Hardware-Aware AI for Embedded Software
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HQ: San Francisco, CA, United States
What they do:
Your phone finally has someone to run it. Plug in Blue, just ask.
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HQ: San Francisco, CA, United States
What they do:
Mass-producing and financing micro data center incredibly quickly.
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HQ: San Francisco, CA, United States
What they do:
Enabling T cell immunotherapy discovery, development and manufacturing
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HQ: San Francisco, CA, United States
What they do:
iPhone-based driver monitoring for commercial fleets.
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HQ: San Francisco, CA, United States
Spice Data
Hiring
What they do:
Restaurant Data for the Enterprise
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HQ: San Francisco, CA, United States
YC S19Early stage
What they do:
Elevating mental health to be a part of your daily coffee ritual.
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HQ: San Francisco, CA, United States
What they do:
Autonomous street sweeping as a service by retro-fitting vehicles
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HQ: San Francisco, CA, United States
What they do:
Search and automation for engineer-to-order companies
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HQ: San Francisco, CA, United States
What they do:
Your biopharma team, from molecule design to portfolio strategy
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HQ: San Francisco, CA, United States
Automat
Hiring
What they do:
Agentic automation that understands context, recovers, and improves.
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HQ: San Francisco, CA, United States
YC W23Growth stage
What they do:
AI for ASIC Design Verification
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HQ: San Francisco, CA, United States
What they do:
Unified flight software and hardware for the mission of tomorrow
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HQ: San Francisco, CA, United States
What they do:
Starbucks app for restaurants
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HQ: San Francisco, CA, United States
What they do:
Gen AI molecular simulations that reproduce wetlab results
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HQ: San Francisco, CA, United States
What they do:
Automating airport baggage handling with robots.
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HQ: San Francisco, CA, United States
YC S24Early stage
Partcl
Hiring
What they do:
Design a chip in minutes
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HQ: San Francisco, CA, United States
YC X25Early stage
What they do:
Voice AI teams for medicare agencies.
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HQ: San Francisco, CA, United States
What they do:
AI-powered robotics for scientific lab automation.
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HQ: San Francisco, CA, United States
Relling
Hiring
What they do:
deploying the first billion robots for manufacturing
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
The GD&T Analysis Platform for Engineering Drawings
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HQ: San Francisco, CA, United States
Juxta
Hiring
What they do:
Building a GPS alternative 100x more powerful with no hardware needed.
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
Manipulate Anything Robot
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HQ: San Francisco, CA, United States
What they do:
A new kind of camera that can see through walls.
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HQ: San Francisco, CA, United States
What they do:
Agents that run short-term rental operations end-to-end
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HQ: San Francisco, CA, United States
What they do:
The first wearable that reads your emotions to enhance your EQ.
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HQ: San Francisco, CA, United States