What they do:
Building drone swarms that hunt hidden enemies.
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HQ: San Francisco, CA, United States
Top Deep Tech Startups in the United States
This list has 1,386 startups and was last updated on Oct 15, 2026. 306 of them are hiring right now. Biggest hubs: San Francisco (704), New York (137), and Los Angeles (79). Largest teams: DoorDash, EquipmentShare, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
1,386 startupsPage 17 of 39
What they do:
AI-native procurement services for the physical economy
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HQ: San Francisco, CA, United States
What they do:
Unmanned cargo airplanes
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HQ: Los Angeles, CA, United States
What they do:
Microgrids in a box built anywhere in days
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HQ: San Francisco, CA, United States
What they do:
Automating away manual admin for food distributors: texts to ERP
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HQ: San Francisco, CA, United States
What they do:
Robots for high skilled labor powering AI infrastructure
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HQ: San Francisco, CA, United States
What they do:
Real-time cloud inference for robotics.
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HQ: San Francisco, CA, United States
What they do:
Shire uses CCTV to run restaurants in real time.
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HQ: Myrtle Beach, SC, United States
What they do:
Enable robots to operate safely in the real world.
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HQ: San Francisco, CA, United States
What they do:
One app for stress-free shopping, cooking, and meal planning.
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HQ: Missoula, MT, United States
What they do:
Skyscrape makes temperature-responsive insulation
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HQ: Portland, OR, United States
What they do:
Cutting edge hydrofoil systems for boatbuilders
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HQ: San Francisco, CA, United States
What they do:
Last-mile delivery for perishables.
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HQ: San Francisco, CA, United States
What they do:
The neural engine for autonomous robots
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HQ: St. Louis, MO, United States
What they do:
Using DNA to store data.
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HQ: Boston, MA, United States
What they do:
Growing micro-organs to find new drugs
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HQ: San Francisco, CA, United States
What they do:
Helping physicians select the right therapy for breast cancer patients
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HQ: Austin, TX, United States
What they do:
Platform to automate manual back-office work
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HQ: San Francisco, CA, United States
What they do:
The AI platform for CRE investment teams
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HQ: San Francisco, CA, United States
What they do:
The Data Platform for Mission‑Critical Systems
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HQ: San Francisco, CA, United States
What they do:
AI chips for ultra-fast training and inference
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HQ: San Francisco, CA, United States
What they do:
AI back office for food product quality teams
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HQ: Los Angeles, CA, United States
What they do:
High precision AI weather
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HQ: Ann Arbor, MI, United States
What they do:
Optimize performance on GPUs - 10x faster
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HQ: New York, NY, United States
What they do:
AI Copilot for Property Managers and Landlords
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HQ: Austin, TX, United States
What they do:
Foundation Model for Chemical Manufacturing
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HQ: San Francisco, CA, United States
What they do:
Batteries and solar for $0 upfront to help businesses save money
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HQ: San Francisco, CA, United States
What they do:
An AI-powered test and debug platform for chip developers
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HQ: New York, NY, United States
What they do:
Config Management for Robotics
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HQ: San Francisco, CA, United States
What they do:
Gigascale Nanomanufacturing
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HQ: San Francisco, CA, United States
What they do:
A stealth mode startup.
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HQ: San Francisco, CA, United States
What they do:
Engineering microbes for miners to unlock billions in trapped metal
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HQ: San Francisco, CA, United States
What they do:
Datadog for industrial robots
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HQ: San Francisco, CA, United States
What they do:
AI teammate for finance and operations teams at consumer brands
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HQ: New York, NY, United States
What they do:
The AI infrastructure for cash-flow-aligned business rent
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HQ: Miami, FL, United States
What they do:
The reliability platform for last-mile delivery
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HQ: New York, NY, United States