What they do:
Building the Operating System for B&M Retail using Deep Learning
Quick facts:
HQ: San Francisco, CA, United States
Top Deep Tech Startups in the United States
This list has 1,386 startups and was last updated on Oct 15, 2026. 306 of them are hiring right now. Biggest hubs: San Francisco (704), New York (137), and Los Angeles (79). Largest teams: DoorDash, EquipmentShare, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
1,386 startupsPage 2 of 39
Mashgin
Hiring
What they do:
Self-Checkout using Computer Vision.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Building the world's first fusion power plant
Quick facts:
HQ: Seattle, WA, United States
What they do:
Zerocater is revolutionizing how companies feed their employees
Quick facts:
HQ: Chicago, IL, United States
What they do:
Artificial intelligence for drug discovery.
Quick facts:
HQ: San Francisco, CA, United States
Funding:
$19.8M · Equity · Mar 2026
Goldbelly
Hiring
What they do:
Empowering restaurants and small food makers to ship nationwide.
Quick facts:
HQ: New York, NY, United States
Gridware
Hiring
What they do:
Protecting the grid today, preparing the grid for tomorrow
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Making car ownership and management frictionless.
Quick facts:
HQ: Nashville, TN, United States
Multiply Labs
Hiring
What they do:
Robotic production capacity for the pharma manufacturing industry
Quick facts:
HQ: San Francisco, CA, United States
Funding:
$75M · Series B · Oct 2026
What they do:
Building a world where alternative proteins are no longer alternative.
Quick facts:
HQ: Washington, DC, United States
Curri
Hiring
What they do:
Construction & industrial logistics platform.
Quick facts:
HQ: Los Angeles, CA, United States
Community Phone Company
Hiring
What they do:
The phone that gives families peace of mind about aging parents
Quick facts:
HQ: San Francisco, CA, United States
Eight Sleep
Hiring
What they do:
The sleep fitness company.
Quick facts:
HQ: New York, NY, United States
Human Archive
Hiring
What they do:
Physical AI data lab
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Sunrun for the developing world
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HQ: New York, NY, United States
What they do:
Your AI partner for North America truckload freight
Quick facts:
HQ: New York, NY, United States
What they do:
We build cities for people, not cars.
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HQ: San Francisco, CA, United States
What they do:
all-in-one operating system (OS) for telcos
Quick facts:
HQ: Remote, OR, United States
Ridecell
Hiring
What they do:
World's Leading Fleet Intelligence Platform
Quick facts:
HQ: San Francisco, CA, United States
Beyond Reach Labs
Hiring
What they do:
Space solar arrays that grow to the size of a football field in orbit
Quick facts:
HQ: New York, NY, United States
Funding:
$10M · Oct 2026
What they do:
UpEquity gives homebuyers more certainty and power.
Quick facts:
HQ: Austin, TX, United States
Broccoli AI
Hiring
What they do:
AI-native operating system for home service businesses
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Absorbable wrap for blood vessels
Quick facts:
HQ: Houston, TX, United States
Funding:
$10M · Debt · May 2026
Sygaldry Technologies
Hiring
What they do:
quantum-accelerated AI servers
Quick facts:
HQ: Ann Arbor, MI, United States
Funding:
$139M · Equity · Apr 2026
PermitFlow
Hiring
What they do:
Construction's AI Platform
Quick facts:
HQ: New York, NY, United States
HappyRobot
Hiring
What they do:
Intelligence that runs your operations.
Quick facts:
HQ: San Francisco, CA, United States
AtoB
Hiring
What they do:
Modernizing global transportation payments.
Quick facts:
HQ: San Francisco, CA, United States
Inspectify
Hiring
What they do:
Home Inspections, Simplified
Quick facts:
HQ: Seattle, WA, United States
What they do:
Robots for longer-lasting, better-tasting fish at scale.
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HQ: Los Angeles, CA, United States
What they do:
Raptor Maps builds software to manage the solar PV lifecycle.
Quick facts:
HQ: Boston, MA, United States
VergeSense
Hiring
What they do:
AI-Powered Building Management
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Autonomous electric airplanes
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Next-generation DNA synthesis using enzymes
Quick facts:
HQ: San Francisco, CA, United States
Mason
Hiring
What they do:
Mason is the fastest way to take smart devices from idea to end user
Quick facts:
HQ: Seattle, WA, United States
What they do:
Shef is a Marketplace for Homemade Food
Quick facts:
HQ: San Francisco, CA, United States
BeGo
Hiring
What they do:
BeGo Connects cargo shippers with truck suppliers in Mexico and US
Quick facts:
HQ: San Francisco, CA, United States