What they do:
Green Canopy NODE builds sustainable homes fast.
Quick facts:
HQ: Seattle, WA, United States
Top Deep Tech Startups in the United States
This list has 1,386 startups and was last updated on Oct 15, 2026. 306 of them are hiring right now. Biggest hubs: San Francisco (704), New York (137), and Los Angeles (79). Largest teams: DoorDash, EquipmentShare, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
1,386 startupsPage 5 of 39
What they do:
Bathroom cleaning robots for office buildings.
Quick facts:
HQ: Miami Beach, FL, United States
Weave Robotics
Hiring
What they do:
Practical and delightful home robots
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Personalized Performance Nutrition
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HQ: New York, NY, United States
What they do:
Autonomous drones to help warehouses scan inventory.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI customer reputation & performance management for restaurant chains.
Quick facts:
HQ: New York, NY, United States
Seam
Hiring
What they do:
API for IoT Devices
Quick facts:
HQ: San Francisco, CA, United States
What they do:
CRISPR powered Diagnostics with results in minutes.
Quick facts:
HQ: San Diego, CA, United States
Charge Robotics
Hiring
What they do:
Robots that build solar farms
Quick facts:
HQ: San Francisco, CA, United States
Invert
Hiring
What they do:
Data analytics software for biomanufacturing.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
We're building satellites to create a real-time 3D map of the world.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Engineering the future of chemistry for natural resource extraction
Quick facts:
HQ: Austin, TX, United States
Polymath Robotics
Hiring
What they do:
General Autonomy for Industrial Vehicles
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Mass-produced AI strike systems and Counter-UAS
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Targeting Cancer with Click Chemistry
Quick facts:
HQ: San Francisco, CA, United States
SnapMagic
Hiring
What they do:
AI-assisted electronics design
Quick facts:
HQ: San Francisco, CA, United States
ArchForm
Hiring
What they do:
Replacing orthodontic braces with our clear aligner and software
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Turning space into a transportation layer for Earth
Quick facts:
HQ: Los Angeles, CA, United States
Blissway
Hiring
What they do:
The tolling industry’s prime tech infrastructure
Quick facts:
HQ: Denver, CO, United States
Tandem
Hiring
What they do:
AI-native office leasing broker
Quick facts:
HQ: San Francisco, CA, United States
What they do:
We build robots for dull, dirty, and dangerous jobs.
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HQ: Charlotte, NC, United States
Kingdom
Hiring
What they do:
Clinically-validated ingredients from natural microbes
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HQ: New York, NY, United States
New Story
Hiring
What they do:
We pioneer solutions to end the global housing crisis by empowering…
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HQ: Atlanta, GA, United States
What they do:
Advano is a battery technology company that improve the longevity of…
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HQ: New Orleans, LA, United States
What they do:
Enabling next generation medicines. A comprehensive platform and…
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HQ: San Francisco, CA, United States
What they do:
We use solar and wind power to make zero net carbon electrofuels
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HQ: Santa Cruz, CA, United States
What they do:
Automated tooth cutting for dentists using imaging, AI and robotics
Quick facts:
HQ: Boston, MA, United States
Handoff
Hiring
What they do:
AI estimator & agent for remodelers.
Quick facts:
HQ: Austin, TX, United States
What they do:
AI-native Robotics
Quick facts:
HQ: Boston, MA, United States
Parallel Bio
Hiring
What they do:
Using the immune system to cure disease
Quick facts:
HQ: San Francisco, CA, United States
HOMLI
Hiring
What they do:
Sell your home without brokers
Quick facts:
HQ: New York, NY, United States
FleetWorks
Hiring
What they do:
AI enabled marketplace matching trucks with jobs
Quick facts:
HQ: San Francisco, CA, United States
Merlin AI
Hiring
What they do:
AI powered ERP for Construction
Quick facts:
HQ: Los Angeles, CA, United States
9 Mothers
Hiring
What they do:
Counter Drone Systems. $1.6m sales. We delivered for the DoW.
Quick facts:
HQ: Austin, TX, United States
What they do:
The financial foundation for every real estate development decision
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HQ: Denver, CO, United States
JITX
Hiring
What they do:
Automatic circuit board design.
Quick facts:
HQ: San Francisco, CA, United States