Electric Air
Hiring
What they do:
Tech-enabled heat pump contractor that cuts costs by 60%
Quick facts:
HQ: San Francisco, CA, United States
Top Deep Tech Startups in the United States
This list has 1,386 startups and was last updated on Oct 15, 2026. 306 of them are hiring right now. Biggest hubs: San Francisco (704), New York (137), and Los Angeles (79). Largest teams: DoorDash, EquipmentShare, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
1,386 startupsPage 6 of 39
What they do:
Next-generation mRNA platform to solve cancer, COVID and climate.
Quick facts:
HQ: Boston, MA, United States
What they do:
ZBiotics makes genetically engineered probiotics.
Quick facts:
HQ: San Francisco, CA, United States
Topkey
Hiring
What they do:
Topkey is the all-in-one financial operating platform that simplifies expense management for hospitality managers.
Quick facts:
HQ: San Francisco, CA, United States
Deepnight
Hiring
What they do:
Building The Next Generation of Night Vision Devices
Quick facts:
HQ: San Francisco, CA, United States
Oway
Hiring
What they do:
Building the open operating system for the automated physical economy.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Copia's a for-profit technology company that solves food waste &…
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Data integration & insights for state and local governments
Quick facts:
HQ: Boston, MA, United States
Sourcify
Hiring
What they do:
Sourcify helps brands manufacture products in Asia.
Quick facts:
HQ: Salt Lake City, UT, United States
What they do:
Arpeggio Bio develops drugs targeting transcription factors using AI…
Quick facts:
HQ: Boulder, CO, United States
Haven
Hiring
What they do:
Homeownership reimagined for the 21st century.
Quick facts:
HQ: New York, NY, United States
General Proximity
Hiring
What they do:
The next generation of induced-proximity medicines.
Quick facts:
HQ: San Francisco, CA, United States
arnata
Hiring
What they do:
AI workers for the logistics industry.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Remote labor for restaurants
Quick facts:
HQ: Memphis, TN, United States
DigiBuild
Hiring
What they do:
We buy & track building materials for construction companies.
Quick facts:
HQ: Miami, FL, United States
Truss
Hiring
What they do:
Truss is a banking and payments network for blue-collar trades.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Water risk mitigation for industrial sites
Quick facts:
HQ: San Francisco, CA, United States
Turion Space
Hiring
What they do:
Moving Things Around in Space, Imaging Space Objects When We're Not
Quick facts:
HQ: Los Angeles, CA, United States
UNISON
Hiring
What they do:
Live between worlds, in UNISON, using the headset we're building!
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Underwater robotic vehicles that collect battery metals responsibly
Quick facts:
HQ: Los Angeles, CA, United States
Cofactr
Hiring
What they do:
Cloud pre-factory logistics and procurement for electronics
Quick facts:
HQ: New York, NY, United States
Conduit
Hiring
What they do:
The operating system for shipping and receiving.
Quick facts:
HQ: San Francisco, CA, United States
dili
Hiring
What they do:
Automating Compliance for Construction
Quick facts:
HQ: New York, NY, United States
What they do:
AI Applied Research
Quick facts:
HQ: San Francisco, CA, United States
Guardian RF
Hiring
What they do:
Drone detection for US defense and national security
Quick facts:
HQ: Washington, DC, United States
No Logo
Hiring
What they do:
Turn ideas into physical products
Quick facts:
HQ: New York, NY, United States
What they do:
Automating Deal Decks for Commercial Real Estate Brokers
Quick facts:
HQ: New York, NY, United States
SalesPatriot
Hiring
What they do:
Supply chain superintelligence for distribution and procurement
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Investment management platform for real estate
Quick facts:
HQ: Seattle, WA, United States
What they do:
We make vanpool simple.
Quick facts:
HQ: Los Angeles, CA, United States
What they do:
Fermentation-derived natural products to solve health problems
Quick facts:
HQ: San Diego, CA, United States
Reform
Hiring
What they do:
AI Agents for high-stakes work.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Drone submarines
Quick facts:
HQ: Philadelphia, PA, United States
What they do:
Your voice. Your health. We care.
Quick facts:
HQ: San Francisco, CA, United States
Sorting Robotics
Hiring
What they do:
We create automation technology for the cannabis industry.
Quick facts:
HQ: Los Angeles, CA, United States
FIRST
Hiring
What they do:
The best way for any business to offer delivery.
Quick facts:
HQ: Philadelphia, PA, United States