What they do:
Mobile app and coaching program that helps employees sleep better
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HQ: San Francisco, CA, United States
Top Digital Health Startups in California
This list has 210 startups and was last updated on Oct 15, 2026. 61 of them are hiring right now. Biggest hubs: San Francisco (190), Los Angeles (12), and San Diego (2). Largest teams: Truepill, Clipboard, and Athelas. Latest round: Malama Health raised $5.32M (Feb 26, 2026).
210 startupsPage 4 of 6
What they do:
Activating an overlooked force in medicine - the patient.
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HQ: San Francisco, CA, United States
What they do:
Foundation models to automate x-ray analysis for radiologists
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HQ: San Francisco, CA, United States
What they do:
AI Voice callers for healthcare billing teams
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HQ: San Francisco, CA, United States
What they do:
YourChoice therapeutics is revolutionizing the contraceptive market…
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HQ: San Francisco, CA, United States
What they do:
Our mobile app reduces chronic pain for 100 million Americans.
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HQ: Los Angeles, CA, United States
What they do:
Float is the full-stack platform for Specialty Pharma
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HQ: Carlsbad, CA, United States
What they do:
Automating home care agency operations with AI
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HQ: San Francisco, CA, United States
What they do:
AI Agents to win denied health insurance claims.
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HQ: San Francisco, CA, United States
What they do:
AI outpatient care workforce
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HQ: San Francisco, CA, United States
What they do:
Foundation models for planning orthopedic surgery
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HQ: San Francisco, CA, United States
What they do:
24/7 Personal Health & Longevity Companion
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HQ: San Francisco, CA, United States
What they do:
AI-Native FDA Regulatory Services
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HQ: San Francisco, CA, United States
What they do:
Oura Ring for Skin
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HQ: San Francisco, CA, United States
What they do:
A tool for pharmacists to find funding for patients who are unable to…
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HQ: Milpitas, CA, United States
What they do:
23andMe for environmental exposures
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HQ: San Francisco, CA, United States
What they do:
Neurostimulation implant to restore hearing & speech understanding
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HQ: San Francisco, CA, United States
What they do:
Reinventing respiration monitoring
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HQ: Los Angeles, CA, United States
What they do:
AI Diagnosis of Heart Disease
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HQ: San Francisco, CA, United States
What they do:
AI assisted documentation for PT/OT/SLP
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HQ: San Francisco, CA, United States
What they do:
Single source of truth for your clinic's finances and supply chain.
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HQ: San Francisco, CA, United States
What they do:
ML to predict and prevent pregnancy complications
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HQ: San Diego, CA, United States
What they do:
Mobile app helping people better manage chronic health conditions
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HQ: San Francisco, CA, United States
What they do:
Modern patient engagement and remote therapeutic monitoring platform
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HQ: San Francisco, CA, United States
What they do:
AI physical therapy for athletes
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HQ: San Francisco, CA, United States
What they do:
AI front office assistant for physical therapy
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HQ: San Francisco, CA, United States
What they do:
Autonomous intake and RCM for specialty clinics.
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HQ: San Francisco, CA, United States
What they do:
Automated physician scheduling
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HQ: San Francisco, CA, United States
What they do:
Voice AI for medical language translation
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HQ: San Francisco, CA, United States
What they do:
The health coach that texts you first
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HQ: San Francisco, CA, United States
What they do:
AI agents for conversational commerce
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HQ: San Francisco, CA, United States
What they do:
RWE Generation in minutes
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HQ: San Francisco, CA, United States
What they do:
Sandboxes for AI agents
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HQ: San Francisco, CA, United States
What they do:
AI-native patient engagement
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HQ: San Francisco, CA, United States
What they do:
Infra to make AI safe enough to practice medicine
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HQ: San Francisco, CA, United States
What they do:
Turns EHR data into study-ready datasets for hospital research teams
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HQ: San Francisco, CA, United States