What they do:
Your health plan should get better year-round. Not just once a year.
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HQ: San Francisco, CA, United States
Top Digital Health Startups in California
This list has 210 startups and was last updated on Oct 15, 2026. 61 of them are hiring right now. Biggest hubs: San Francisco (190), Los Angeles (12), and San Diego (2). Largest teams: Truepill, Clipboard, and Athelas. Latest round: Malama Health raised $5.32M (Feb 26, 2026).
210 startupsPage 5 of 6
What they do:
Empowering Physical Therapists to Go Independent
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HQ: San Francisco, CA, United States
What they do:
Monitoring and governance for deployed medical imaging AI
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HQ: San Francisco, CA, United States
What they do:
Customized fertility benefits for modern companies.
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HQ: San Francisco, CA, United States
YC S17Growth stage
What they do:
AI operating system for veterinary care
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HQ: San Francisco, CA, United States
YC W24Early stage
What they do:
The full-stack AI CRO for drug discovery.
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HQ: San Francisco, CA, United States
YC F26Early stage
DrChrono
Acquired
What they do:
The essential platform for modern medical practices and patients.
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HQ: San Francisco, CA, United States
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HQ: San Francisco, CA, United States
Truepill
Acquired
What they do:
API-connected healthcare infrastructure.
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HQ: San Francisco, CA, United States
Memora Health
Acquired
What they do:
Digitize and Automate Complex Care Workflows
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HQ: San Francisco, CA, United States
Spire Health
Acquired
What they do:
Remote patient monitoring for lung disease patients.
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HQ: San Francisco, CA, United States
Comprehend
Acquired
What they do:
SaaS to increase speed and quality of clinical trials.
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HQ: San Francisco, CA, United States
Science Exchange
Acquired
What they do:
Powering scientific outsourcing
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HQ: San Francisco, CA, United States
HeyDoctor
Acquired
What they do:
HeyDoctor provides online primary care (like refilling birth control,…
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HQ: San Francisco, CA, United States
Enzyme
Acquired
What they do:
Automating regulatory approval & compliance for life science companies
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HQ: San Francisco, CA, United States
HappiLabs
Acquired
What they do:
Virtual Lab Managers for scientists and biotech, research Labs
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HQ: San Francisco, CA, United States
Scanwell Health
Acquired
What they do:
Smartphone-enabled, at-home diagnostics
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HQ: Los Angeles, CA, United States
PlateJoy
Acquired
What they do:
PlateJoy is building the technology to power disease prevention and…
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HQ: San Francisco, CA, United States
Able Health
Acquired
What they do:
Able Health gets doctors paid more for higher quality care
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HQ: San Francisco, CA, United States
Sepsis Scout
Acquired
What they do:
Wearables and AI to predict and prevent sepsis outside the hospital
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HQ: San Francisco, CA, United States
Furmacy
Acquired
What they do:
Digital e-prescribing software for veterinarians.
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HQ: San Francisco, CA, United States
Sample
Acquired
What they do:
Flexible systems for clinical reasoning.
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HQ: San Francisco, CA, United States
Dear Brightly
Acquired
What they do:
Dear Brightly makes personalized prescription skincare products,…
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HQ: San Francisco, CA, United States
Verano Health
Acquired
What they do:
Nonprofit telehealth coaches for underserved Americans on Medicaid
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HQ: San Francisco, CA, United States
Verse Therapy
Acquired
What they do:
Connecting All Ages with Speech Language Pathologists
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HQ: San Francisco, CA, United States
MedXT
Acquired
What they do:
Radiology in the cloud. X-rays, CAT scans, MRI's, and…
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HQ: San Francisco, CA, United States
ListRunner
Acquired
What they do:
Replaces paper patient lists for doctors.
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HQ: San Francisco, CA, United States
Kip Health
Acquired
What they do:
Therapy the way it should be: high quality in-person therapy sessions…
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HQ: San Francisco, CA, United States
onederful
Acquired
What they do:
Dental Insurance API
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HQ: San Francisco, CA, United States
Sayana
Acquired
What they do:
Affordable mental self-care for all. Acquired by Headspace Health.
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HQ: San Francisco, CA, United States
Docbot
Acquired
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HQ: Los Angeles, CA, United States
YC W19Growth stage
Medinas Health
Shut down
What they do:
Medinas helps hospitals manage their inventory and buy and sell their…
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HQ: San Francisco, CA, United States
Transcriptic
Shut down
What they do:
The robotic cloud laboratory for the life sciences.
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HQ: San Francisco, CA, United States
Medisas
Shut down
What they do:
Medisas builds workflow & collaboration software for hospitals.
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HQ: San Francisco, CA, United States
Klarismo
Shut down
What they do:
Klarismo turns your body into an interactive experience. We built a…
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HQ: San Francisco, CA, United States
Clip Health
Shut down
What they do:
Testing & treatment at home, in minutes, for chronic & acute disease
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HQ: San Francisco, CA, United States