What they do:
One clinic for every sleep issue
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HQ: San Francisco, CA, United States
Top Digital Health Startups in San Francisco
This list has 190 startups and was last updated on Oct 15, 2026. 58 of them are hiring right now. Largest teams: Truepill, Clipboard, and Athelas. Latest round: Malama Health raised $5.32M (Feb 26, 2026).
190 startupsPage 3 of 6
What they do:
Early detection of Alzheimer's disease
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HQ: San Francisco, CA, United States
What they do:
AI workers that book, scribe, code, interpret, and answer clinicians
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HQ: San Francisco, CA, United States
What they do:
Portable cryoablation to prevent cervical cancer
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HQ: San Francisco, CA, United States
Reviving Mind
Hiring
What they do:
Addressing Loneliness and Isolation for Seniors
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HQ: San Francisco, CA, United States
Quill Bills
Hiring
What they do:
AI-Powered Medical Billing
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HQ: San Francisco, CA, United States
Klarify
Hiring
What they do:
AI Agent for Therapists
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HQ: San Francisco, CA, United States
Allia Health
Hiring
What they do:
AI-Native Medical Group for Mental Health
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HQ: San Francisco, CA, United States
What they do:
Group-Therapy Platform for Providers and Health Systems
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HQ: San Francisco, CA, United States
Delfino AI
Hiring
What they do:
Generative AI for administrative automation in healthcare
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HQ: San Francisco, CA, United States
Layers
Hiring
What they do:
Improve your appearance by measuring, understanding, and tracking…
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HQ: San Francisco, CA, United States
Taiga
Hiring
What they do:
Autonomous medical billing
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HQ: San Francisco, CA, United States
What they do:
At-home oral health testing, coaching & care
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HQ: San Francisco, CA, United States
What they do:
Scheduling software for digital health clinics to do more with less.
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HQ: San Francisco, CA, United States
What they do:
AI workforce management for healthcare
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HQ: San Francisco, CA, United States
What they do:
A research lab for one
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HQ: San Francisco, CA, United States
What they do:
The AI operating system for radiology networks
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HQ: San Francisco, CA, United States
What they do:
The lifestyle medicine layer for clinicians.
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HQ: San Francisco, CA, United States
What they do:
Entvin is building AI agents specifically designed to support regulatory teams in the life sciences industry. Our platform leverages AI to streamline…
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HQ: San Francisco, CA, United States
Knowtex
Hiring
What they do:
Making doctors 2x more efficient with AI note-taking & charge capture
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HQ: San Francisco, CA, United States
What they do:
At-cost preventive health: Labs, Scans, Genetics, Supplements and Rx
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HQ: San Francisco, CA, United States
What they do:
Helping hospitals identify and prevent avoidable harm using AI
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HQ: San Francisco, CA, United States
What they do:
AI agents for risk-bearing healthcare organizations
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HQ: San Francisco, CA, United States
What they do:
Adaptive training coach for runners, cyclists, and triathletes
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HQ: San Francisco, CA, United States
Plena Health
Hiring
What they do:
Plena is the AI operating system for specialty medical practices
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HQ: San Francisco, CA, United States
YC X26Early stage
What they do:
Full Stack Pharmaceutical Company for Personalized Peptides and GLP-1s
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HQ: San Francisco, CA, United States
What they do:
Mobile app and coaching program that helps employees sleep better
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HQ: San Francisco, CA, United States
What they do:
Activating an overlooked force in medicine - the patient.
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HQ: San Francisco, CA, United States
What they do:
Foundation models to automate x-ray analysis for radiologists
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HQ: San Francisco, CA, United States
What they do:
AI Voice callers for healthcare billing teams
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HQ: San Francisco, CA, United States
What they do:
YourChoice therapeutics is revolutionizing the contraceptive market…
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HQ: San Francisco, CA, United States
What they do:
Automating home care agency operations with AI
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HQ: San Francisco, CA, United States
What they do:
AI Agents to win denied health insurance claims.
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HQ: San Francisco, CA, United States
What they do:
AI outpatient care workforce
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HQ: San Francisco, CA, United States
What they do:
Foundation models for planning orthopedic surgery
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HQ: San Francisco, CA, United States
What they do:
24/7 Personal Health & Longevity Companion
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HQ: San Francisco, CA, United States