What they do:
Point of Sale and Compliance SaaS for Cannabis Dispensaries
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HQ: San Francisco, CA, United States
Top E-commerce Startups in California
This list has 171 startups and was last updated on Oct 15, 2026. 31 of them are hiring right now. Biggest hubs: San Francisco (142) and Los Angeles (20). Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Modal raised $750M (Oct 14, 2026).
171 startupsPage 2 of 5
What they do:
Upgraded helps retailers and carriers sell devices on subscription.
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HQ: San Francisco, CA, United States
Prox
Hiring
What they do:
AI product specialists for equipment manufacturers
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HQ: San Francisco, CA, United States
What they do:
Online Auctions for Authentic (Women's) Designer Goods
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HQ: San Francisco, CA, United States
What they do:
E-commerce 2.0
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HQ: San Francisco, CA, United States
Anglera
Hiring
What they do:
AI-Powered Product Data Enrichment
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HQ: San Francisco, CA, United States
What they do:
StyleUp brings effortless joy to getting dressed with daily,…
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HQ: San Francisco, CA, United States
What they do:
The secret backbone of e-commerce.
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HQ: San Francisco, CA, United States
What they do:
Buying and owning indoor potted plants made easy.
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HQ: Los Angeles, CA, United States
Pillar
Hiring
What they do:
All-In-One Creator Store
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HQ: San Francisco, CA, United States
Turing Labs Inc.
Hiring
What they do:
AI for R&D of consumer brands like P&G to develop better products
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HQ: San Francisco, CA, United States
BetterBasket
Hiring
What they do:
Smart grocery pricing with AI
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HQ: San Francisco, CA, United States
What they do:
Opentable for the world's top restaurants; we help them increase…
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HQ: San Francisco, CA, United States
What they do:
AI Agent for Home Design
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HQ: Los Angeles, CA, United States
Scout
Hiring
What they do:
AI insights for consumer products
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HQ: San Francisco, CA, United States
GloGlo
Hiring
What they do:
Curing and preventing type 1 diabetes
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HQ: San Francisco, CA, United States
Refactor
Hiring
What they do:
Deploying secure and reliable AI agents across healthcare, retail,…
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HQ: San Francisco, CA, United States
Amboras
Hiring
What they do:
AI Native Shopify
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HQ: San Francisco, CA, United States
What they do:
Lucy’s mission is to reduce tobacco-related harm to zero. We provide…
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HQ: Los Angeles, CA, United States
Hellometer
Hiring
What they do:
Making fast food faster
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HQ: Los Angeles, CA, United States
Layers
Hiring
What they do:
Improve your appearance by measuring, understanding, and tracking…
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HQ: San Francisco, CA, United States
What they do:
Frictionless payments via SMS
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HQ: San Francisco, CA, United States
What they do:
The fastest way to sell online.
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HQ: San Francisco, CA, United States
What they do:
Markhor is a DTC company that works with craftsmen to make shoes and…
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HQ: San Francisco, CA, United States
Wildcard
Hiring
What they do:
AEO/GEO for E-Commerce and Retail
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HQ: San Francisco, CA, United States
YC W25Early stage
What they do:
AI-Native Restaurant POS
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HQ: San Francisco, CA, United States
What they do:
Sell beyond the store.
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HQ: San Francisco, CA, United States
What they do:
A direct to consumer marketplace and influencer network for brands
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HQ: Los Angeles, CA, United States
What they do:
Clinical skincare tested on diverse skin, now available in Sephora.
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HQ: San Francisco, CA, United States
What they do:
Fastest, easiest, and most affordable way for small business owners…
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HQ: San Francisco, CA, United States
What they do:
Encarte is building 1-click checkout for all online stores.
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HQ: San Francisco, CA, United States
What they do:
Subscriptions for neighborhood businesses
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HQ: San Francisco, CA, United States
What they do:
Automated phone ordering system for restaurants
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HQ: San Francisco, CA, United States
What they do:
D2C Skincare for Eczema
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HQ: San Francisco, CA, United States
What they do:
The operating system for the car wash industry.
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HQ: Temecula, CA, United States
What they do:
API & SDK for RCS (the next-generation of texting)
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HQ: San Francisco, CA, United States