Top E-commerce Startups in San Francisco

5 employeesYC W20Growth stage

Data & analytics Food & agriculture Applied AI & ML E-commerce & retail

BetterBasket

Hiring

What they do:

Smart grocery pricing with AI

Quick facts:

5 employeesYC W24Early stage

Meitre

What they do:

Opentable for the world's top restaurants; we help them increase…

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9 employeesYC W18Early stageRemote

Food & agriculture Data & analytics Sales & marketing E-commerce & retail

Scout

Hiring

What they do:

AI insights for consumer products

Quick facts:

3 employeesYC W24Early stage

Applied AI & ML Biotech & pharma Wellness & mental health E-commerce & retail

GloGlo

Hiring

What they do:

Curing and preventing type 1 diabetes

Quick facts:

3 employeesYC W24Early stage

AI agents & assistants Applied AI & ML E-commerce & retail

Refactor

Hiring

What they do:

Deploying secure and reliable AI agents across healthcare, retail,…

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3 employeesYC S24Early stage

Applied AI & ML E-commerce & retail

Amboras

Hiring

What they do:

AI Native Shopify

Quick facts:

3 employeesYC X26Early stage

Wellness & mental health Applied AI & ML Digital health & care E-commerce & retail

Layers

Hiring

What they do:

Improve your appearance by measuring, understanding, and tracking…

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2 employeesYC F25Early stage

Payments E-commerce & retail

OneText

What they do:

Frictionless payments via SMS

Quick facts:

6 employeesYC W23Early stageRemote

Applied AI & ML E-commerce & retail Marketplaces

SellRaze

What they do:

The fastest way to sell online.

Quick facts:

6 employeesYC F25Early stage

Markhor

What they do:

Markhor is a DTC company that works with craftsmen to make shoes and…

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5 employeesYC S15Early stageRemote

Applied AI & ML E-commerce & retail Sales & marketing

Wildcard

Hiring

What they do:

AEO/GEO for E-Commerce and Retail

Quick facts:

YC W25Early stage

Applied AI & ML AI agents & assistants Food & agriculture E-commerce & retail

Avocado

What they do:

AI-Native Restaurant POS

Quick facts:

4 employeesYC W21Early stage

Seer

What they do:

Sell beyond the store.

Quick facts:

4 employeesYC W21Early stageRemote

Lion Pose

What they do:

Clinical skincare tested on diverse skin, now available in Sephora.

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3 employeesYC W21Early stageRemote

Logistics & supply chain E-commerce & retail

Cheetah

What they do:

Fastest, easiest, and most affordable way for small business owners…

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2 employeesYC W13Growth stage

Payments E-commerce & retail

Canopy (was Encarte)

What they do:

Encarte is building 1-click checkout for all online stores.

Quick facts:

2 employeesYC W19Early stage

E-commerce & retail Social & community

The Third Place

What they do:

Subscriptions for neighborhood businesses

Quick facts:

2 employeesYC W21Early stage

E-commerce & retail Robotics & drones Food & agriculture

StrideQ

What they do:

Automated phone ordering system for restaurants

Quick facts:

2 employeesYC S21Early stageRemote

SOTERI SKIN

What they do:

D2C Skincare for Eczema

Quick facts:

2 employeesYC W22Early stage

Developer tools Sales & marketing E-commerce & retail

Pinnacle

What they do:

API & SDK for RCS (the next-generation of texting)

Quick facts:

2 employeesYC S24Early stage

Applied AI & ML E-commerce & retail

Riveter

What they do:

Turn the web into structured data

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2 employeesYC F24Early stage

Applied AI & ML Sales & marketing Digital health & care E-commerce & retail

Cenote

What they do:

AI agents for conversational commerce

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2 employeesYC W25Early stage

Signals

What they do:

iMessage revenue channel for DTC brands that brings customers back

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2 employeesYC W26Early stage

Kinect

What they do:

The AI revenue platform for D2C brands

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2 employeesYC X26Early stage

Lygg

What they do:

Building New Anti-Aging Ingredients for Skincare

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1 employeesYC W21Early stage

Applied AI & ML Sales & marketing E-commerce & retail Marketplaces

Palisade

What they do:

AI-native sales agents that run marketplaces

Quick facts:

1 employeesYC S26Early stage

E-commerce & retail Data & analytics

42

What they do:

Analytics stack for omnichannel retailers and brands

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YC W14Early stage

Food & agriculture E-commerce & retail

OpenWrench

What they do:

We help retailers and restaurant chains manage repairs and…

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YC S18Early stage

Accounting & finance ops E-commerce & retail

Synder

What they do:

Easy accounting for e-commerce

Quick facts:

YC S21Early stage

Applied AI & ML Real estate & construction E-commerce & retail

DigitalCarbon

What they do:

Transform Images And Videos Into Immersive 3D With AI

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YC S24Early stage

E-commerce & retail Marketplaces

Fivestars

Acquired

What they do:

Customer loyalty and payments platform for small businesses.

Quick facts:

201 employeesYC W11Growth stage

Allbirds

Quick facts:

E-commerce & retail Marketplaces

Funding:

$3.25M · Debt · May 2026

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Teespring

Acquired

What they do:

IMPORTANT: The original YC founders are no longer involved with this…

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201 employeesYC W13Growth stage

Sales & marketing E-commerce & retail

500Friends

Acquired

What they do:

the best loyalty and retention marketing partner for CMOs.

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51 employeesYC W10Early stage

E-commerce & retail Applied AI & ML Logistics & supply chain

Semantics3

Acquired

What they do:

Data and AI platform for Ecommerce & Cross-Border Logistics

Quick facts:

25 employeesYC W13Early stage