What they do:
Clinical skincare tested on diverse skin, now available in Sephora.
Quick facts:
HQ: San Francisco, CA, United States
Top E-commerce Startups in the United States
This list has 279 startups and was last updated on Oct 15, 2026. 53 of them are hiring right now. Biggest hubs: San Francisco (142), New York (56), and Los Angeles (20). Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Astraea, Inc./DE raised $175K (Oct 14, 2026).
279 startupsPage 4 of 8
What they do:
Neobank for e-commerce businesses
Quick facts:
HQ: New York, NY, United States
What they do:
AI teammate for finance and operations teams at consumer brands
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HQ: New York, NY, United States
What they do:
The reliability platform for last-mile delivery
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HQ: New York, NY, United States
What they do:
Fastest, easiest, and most affordable way for small business owners…
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HQ: San Francisco, CA, United States
What they do:
Encarte is building 1-click checkout for all online stores.
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HQ: San Francisco, CA, United States
What they do:
Subscriptions for neighborhood businesses
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HQ: San Francisco, CA, United States
What they do:
Supply chain finance for consumer brands
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HQ: Honolulu, HI, United States
What they do:
Automated phone ordering system for restaurants
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HQ: San Francisco, CA, United States
What they do:
D2C Skincare for Eczema
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HQ: San Francisco, CA, United States
What they do:
The operating system for the car wash industry.
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HQ: Temecula, CA, United States
What they do:
API & SDK for RCS (the next-generation of texting)
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HQ: San Francisco, CA, United States
What they do:
Turn the web into structured data
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HQ: San Francisco, CA, United States
What they do:
AI agents for conversational commerce
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HQ: San Francisco, CA, United States
What they do:
A vintage marketplace curated by AI
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HQ: New York, NY, United States
What they do:
iMessage revenue channel for DTC brands that brings customers back
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HQ: San Francisco, CA, United States
What they do:
The AI revenue platform for D2C brands
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HQ: San Francisco, CA, United States
What they do:
Building New Anti-Aging Ingredients for Skincare
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HQ: San Francisco, CA, United States
What they do:
AI-native sales agents that run marketplaces
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HQ: San Francisco, CA, United States
What they do:
Analytics stack for omnichannel retailers and brands
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HQ: San Francisco, CA, United States
YC W14Early stage
What they do:
Community-driven marketplace for sneakers.
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HQ: Los Angeles, CA, United States
YC W15Early stage
What they do:
We help retailers and restaurant chains manage repairs and…
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HQ: San Francisco, CA, United States
YC S18Early stage
What they do:
Visual AI shopping
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HQ: New York, NY, United States
YC S21Early stage
What they do:
Easy accounting for e-commerce
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HQ: San Francisco, CA, United States
YC S21Early stage
What they do:
Transform Images And Videos Into Immersive 3D With AI
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HQ: San Francisco, CA, United States
YC S24Early stage
Fivestars
Acquired
What they do:
Customer loyalty and payments platform for small businesses.
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HQ: San Francisco, CA, United States
Quick facts:
HQ: Little Rock, AR, United States
Funding:
$2.39B · Equity · Jun 2026
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HQ: Austin, TX, United States
Incorporated: 2023
Funding:
$27.5M · Equity · Apr 2026
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HQ: New York, NY, United States
Incorporated: 2022
Funding:
$19.8M · Equity · Mar 2026
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HQ: Santa Monica, CA, United States
Funding:
$17.4M · Equity · Apr 2026
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HQ: Lake Elmo, MN, United States
Funding:
$12.4M · Equity · Mar 2026
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HQ: Costa Mesa, CA, United States
Funding:
$10M · Equity · Apr 2026
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HQ: Minneapolis, MN, United States
Funding:
$8.13M · Equity + debt · Jan 2026
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HQ: Hudson, NY, United States
Incorporated: 2021
Funding:
$6.17M · Equity · Feb 2026
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HQ: Missoula, MT, United States
Incorporated: 2022
Funding:
$5.9M · Equity · Mar 2026
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HQ: Wayne, PA, United States
Funding:
$5.13M · Equity · Jan 2026