What they do:
Foundational infrastructure for Physical AI
Quick facts:
HQ: San Francisco, CA, United States
Top Deep Tech Startups in California
This list has 846 startups and was last updated on Oct 15, 2026. 201 of them are hiring right now. Biggest hubs: San Francisco (704), Los Angeles (79), and San Diego (7). Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Circularity Fuels raised $8.79M (Oct 14, 2026).
846 startupsPage 15 of 24
What they do:
We make silicon on the Moon, to power everything in space.
Quick facts:
HQ: Los Angeles, CA, United States
What they do:
Autonomous rovers to make the ‘Google Maps’ of underground utilities
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Automatic Diagnosis & Fix for Industrial Automation Cells
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Deploying robots to replace workers in hazardous spaces
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI tools for the chips your AI runs on
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Floating nuclear powered data centers at sea.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
World's Earliest Test for Alzheimer's Biomarkers
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Agents running industrial enterprises from back office to shop floor
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI for the industries that power America.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Quick-turn, purpose-built motors & actuators for all
Quick facts:
HQ: Los Angeles, CA, United States
What they do:
A consumer brain-computer interface you can map to anything.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
The generalist robot deployment company.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Precision navigation for UAVs operating without GPS.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
On Demand CNC Prototyping
Quick facts:
HQ: San Francisco, CA, United States
What they do:
A foundation model for engineering physics
Quick facts:
HQ: San Francisco, CA, United States
What they do:
voice-first hardware interface for human-agent interaction
Quick facts:
HQ: San Francisco, CA, United States
What they do:
The AI decision engine for factories, warehouses and fleets
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Accelerating scaled plastics with additive technologies
Quick facts:
HQ: El Segundo, CA, United States
What they do:
a phone where AI is the interface
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Lark - AI agents that automate workflows for wholesale distributors
Quick facts:
HQ: San Francisco, CA, United States
What they do:
The pit crew for machines and robots.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Perlara: building the YC for rare disease parents
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Prime Lightworks Inc. manufactures electric propulsion systems for…
Quick facts:
HQ: Culver City, CA, United States
What they do:
Universal, Pure-GPU HTML Renderer
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Multi-agent AI for physical logistics operations
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Redefining the Standard of Care for Iron Deficiency Anemia
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Faster processors for solving NP-complete problems
Quick facts:
HQ: San Diego, CA, United States
What they do:
Specialized agents for real work
Quick facts:
HQ: Los Angeles, CA, United States
What they do:
Building and Protecting an Exciting Future
Quick facts:
HQ: Los Angeles, CA, United States
What they do:
Turning messy inboxes into ERP-Ready Data
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI agents for global trade compliance
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI for the physical world
Quick facts:
HQ: Los Angeles, CA, United States
What they do:
A robotics intelligence system for metal fabrication
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Accelerated Physics Kernels for Computational Engineering
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI-native, hardware procurement marketplace
Quick facts:
HQ: San Francisco, CA, United States