Nine Fives
Hiring
What they do:
RF test equipment for next-gen spacecraft, drones, and cellphones
Quick facts:
HQ: San Francisco, CA, United States
Top Deep Tech Startups in San Francisco
This list has 704 startups and was last updated on Oct 15, 2026. 180 of them are hiring right now. Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Aikido Technologies raised $1.72M (Oct 8, 2026).
704 startupsPage 7 of 20
AquaShield
Hiring
What they do:
AI water leak detection for buildings
Quick facts:
HQ: San Francisco, CA, United States
Neuromorphic
Hiring
What they do:
Building robots to automate wetlabs
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Autonomous construction on Earth and beyond
Quick facts:
HQ: San Francisco, CA, United States
83 Sciences
Hiring
What they do:
AI-native materials discovery powered by unpublished experimental data
Quick facts:
HQ: San Francisco, CA, United States
Vernius Systems, Inc.
Hiring
What they do:
Mass-deployable radars for air defense
Quick facts:
HQ: San Francisco, CA, United States
The Subvocal Company
Hiring
What they do:
Talk to your computer without talking
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Flexible printed OLED displays.
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HQ: San Francisco, CA, United States
What they do:
AWS for precision manufacturing
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HQ: San Francisco, CA, United States
What they do:
Empowering anyone to build cellular network
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HQ: San Francisco, CA, United States
What they do:
Programmable biology company for psychoactive effect design
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HQ: San Francisco, CA, United States
What they do:
AI for product formulation
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HQ: San Francisco, CA, United States
What they do:
Accelerate clinical trials with real-time, actionable insights
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HQ: San Francisco, CA, United States
What they do:
AI Supply Chain Manager for CPG
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HQ: San Francisco, CA, United States
What they do:
An AI physics simulator for AI chip design
Quick facts:
HQ: San Francisco, CA, United States
Mineflow
Hiring
What they do:
Mineflow predicts the shape and location of mineral deposits
Quick facts:
HQ: San Francisco, CA, United States
Zettascale Computing
Hiring
What they do:
Chips for frontier AI
Quick facts:
HQ: San Francisco, CA, United States
Cerulion
Hiring
What they do:
Open source operating system for robots
Quick facts:
HQ: San Francisco, CA, United States
PermitPortal
Hiring
What they do:
AI Operating System for Pre-construction
Quick facts:
HQ: San Francisco, CA, United States
Fresco
Hiring
What they do:
AI copilot for construction estimators
Quick facts:
HQ: San Francisco, CA, United States
Enhanced Radar
Hiring
What they do:
AI for air traffic control
Quick facts:
HQ: San Francisco, CA, United States
Paragon
Hiring
What they do:
The AI Growth Engine for Industrials
Quick facts:
HQ: San Francisco, CA, United States
Chestnut
Hiring
What they do:
The first AI mortgage lender
Quick facts:
HQ: San Francisco, CA, United States
OS3
Hiring
What they do:
Affordable, intelligent humanoid robots built to deploy at scale
Quick facts:
HQ: San Francisco, CA, United States
Waddle Labs
Hiring
What they do:
LLMs that control robots
Quick facts:
HQ: San Francisco, CA, United States
One Robot
Hiring
What they do:
World models for robot evals and training.
Quick facts:
HQ: San Francisco, CA, United States
Ventura
Hiring
What they do:
AI Workforce for Distributors and Manufacturers
Quick facts:
HQ: San Francisco, CA, United States
Terranox AI
Hiring
What they do:
The first AI-powered uranium discovery company
Quick facts:
HQ: San Francisco, CA, United States
Rudus
Hiring
What they do:
AI Takeoffs for Concrete
Quick facts:
HQ: San Francisco, CA, United States
Discovered Materials
Hiring
What they do:
AI scientists to discover materials for the semiconductor industry.
Quick facts:
HQ: San Francisco, CA, United States
HERA
Hiring
What they do:
We make sure every factory in the world builds without mistakes.
Quick facts:
HQ: San Francisco, CA, United States
IMPACT Drones
Hiring
What they do:
Air Defense as a Service for Civilian Infrastructure.
Quick facts:
HQ: San Francisco, CA, United States
Aktoria Robotics
Hiring
What they do:
Human as API for robots
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HQ: San Francisco, CA, United States
What they do:
Drone swarm defence at a small-unit level
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HQ: San Francisco, CA, United States
Edviro
Hiring
What they do:
AI That Operates Energy Infrastructure
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HQ: San Francisco, CA, United States
Rhem Labs
Hiring
What they do:
Home care technology for aging parents and their families
Quick facts:
HQ: San Francisco, CA, United States