What they do:
Autonomous drones to help warehouses scan inventory.
Quick facts:
HQ: San Francisco, CA, United States
Top Deep Tech Startups in California
This list has 846 startups and was last updated on Oct 15, 2026. 201 of them are hiring right now. Biggest hubs: San Francisco (704), Los Angeles (79), and San Diego (7). Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Circularity Fuels raised $8.79M (Oct 14, 2026).
846 startupsPage 3 of 24
Seam
Hiring
What they do:
API for IoT Devices
Quick facts:
HQ: San Francisco, CA, United States
What they do:
CRISPR powered Diagnostics with results in minutes.
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HQ: San Diego, CA, United States
Charge Robotics
Hiring
What they do:
Robots that build solar farms
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HQ: San Francisco, CA, United States
Invert
Hiring
What they do:
Data analytics software for biomanufacturing.
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HQ: San Francisco, CA, United States
What they do:
We're building satellites to create a real-time 3D map of the world.
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HQ: San Francisco, CA, United States
Polymath Robotics
Hiring
What they do:
General Autonomy for Industrial Vehicles
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Mass-produced AI strike systems and Counter-UAS
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HQ: San Francisco, CA, United States
What they do:
Targeting Cancer with Click Chemistry
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HQ: San Francisco, CA, United States
SnapMagic
Hiring
What they do:
AI-assisted electronics design
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HQ: San Francisco, CA, United States
ArchForm
Hiring
What they do:
Replacing orthodontic braces with our clear aligner and software
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Turning space into a transportation layer for Earth
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HQ: Los Angeles, CA, United States
Tandem
Hiring
What they do:
AI-native office leasing broker
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HQ: San Francisco, CA, United States
What they do:
Enabling next generation medicines. A comprehensive platform and…
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HQ: San Francisco, CA, United States
What they do:
We use solar and wind power to make zero net carbon electrofuels
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HQ: Santa Cruz, CA, United States
Parallel Bio
Hiring
What they do:
Using the immune system to cure disease
Quick facts:
HQ: San Francisco, CA, United States
FleetWorks
Hiring
What they do:
AI enabled marketplace matching trucks with jobs
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HQ: San Francisco, CA, United States
Merlin AI
Hiring
What they do:
AI powered ERP for Construction
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HQ: Los Angeles, CA, United States
JITX
Hiring
What they do:
Automatic circuit board design.
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HQ: San Francisco, CA, United States
Electric Air
Hiring
What they do:
Tech-enabled heat pump contractor that cuts costs by 60%
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HQ: San Francisco, CA, United States
What they do:
ZBiotics makes genetically engineered probiotics.
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HQ: San Francisco, CA, United States
Topkey
Hiring
What they do:
Topkey is the all-in-one financial operating platform that simplifies expense management for hospitality managers.
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HQ: San Francisco, CA, United States
Deepnight
Hiring
What they do:
Building The Next Generation of Night Vision Devices
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HQ: San Francisco, CA, United States
Oway
Hiring
What they do:
Building the open operating system for the automated physical economy.
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HQ: San Francisco, CA, United States
What they do:
Copia's a for-profit technology company that solves food waste &…
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HQ: San Francisco, CA, United States
General Proximity
Hiring
What they do:
The next generation of induced-proximity medicines.
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HQ: San Francisco, CA, United States
arnata
Hiring
What they do:
AI workers for the logistics industry.
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HQ: San Francisco, CA, United States
Truss
Hiring
What they do:
Truss is a banking and payments network for blue-collar trades.
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HQ: San Francisco, CA, United States
What they do:
Water risk mitigation for industrial sites
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HQ: San Francisco, CA, United States
Turion Space
Hiring
What they do:
Moving Things Around in Space, Imaging Space Objects When We're Not
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HQ: Los Angeles, CA, United States
UNISON
Hiring
What they do:
Live between worlds, in UNISON, using the headset we're building!
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HQ: San Francisco, CA, United States
What they do:
Underwater robotic vehicles that collect battery metals responsibly
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HQ: Los Angeles, CA, United States
Conduit
Hiring
What they do:
The operating system for shipping and receiving.
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HQ: San Francisco, CA, United States
What they do:
AI Applied Research
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HQ: San Francisco, CA, United States
SalesPatriot
Hiring
What they do:
Supply chain superintelligence for distribution and procurement
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HQ: San Francisco, CA, United States
What they do:
We make vanpool simple.
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HQ: Los Angeles, CA, United States