What they do:
Fermentation-derived natural products to solve health problems
Quick facts:
HQ: San Diego, CA, United States
Top Deep Tech Startups in California
This list has 846 startups and was last updated on Oct 15, 2026. 201 of them are hiring right now. Biggest hubs: San Francisco (704), Los Angeles (79), and San Diego (7). Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Circularity Fuels raised $8.79M (Oct 14, 2026).
846 startupsPage 4 of 24
Reform
Hiring
What they do:
AI Agents for high-stakes work.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Your voice. Your health. We care.
Quick facts:
HQ: San Francisco, CA, United States
Sorting Robotics
Hiring
What they do:
We create automation technology for the cannabis industry.
Quick facts:
HQ: Los Angeles, CA, United States
Farcast
Hiring
What they do:
We build advanced satcom user terminals
Quick facts:
HQ: San Francisco, CA, United States
Andromeda Surgical
Hiring
What they do:
Autonomous surgical robots
Quick facts:
HQ: San Francisco, CA, United States
RetailReady
Hiring
What they do:
An AI-powered supply chain compliance engine
Quick facts:
HQ: San Francisco, CA, United States
Cartage
Hiring
What they do:
Autonomous freight coordination
Quick facts:
HQ: San Francisco, CA, United States
Assembly HOA
Hiring
What they do:
AI-native HOA Management Company
Quick facts:
HQ: San Francisco, CA, United States
Odys Aviation
Hiring
What they do:
Vertical takeoff and landing aircraft for major airlines
Quick facts:
HQ: Los Angeles, CA, United States
What they do:
Nuclear-inspired cooling that turns wasted power into more AI compute
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HQ: San Francisco, CA, United States
AirMyne
Hiring
What they do:
Building systems to remove carbon dioxide from air at industrial scale
Quick facts:
HQ: San Francisco, CA, United States
Lanesurf
Hiring
What they do:
Book any load in 10 minutes
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Curtsy is a sustainable clothing resale app.
Quick facts:
HQ: San Francisco, CA, United States
Vorticity
Hiring
What they do:
The Fastest Scientific Computing Platform on the Planet
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Route Optimisation platform for SMB in delivery & home services.
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HQ: San Francisco, CA, United States
What they do:
Using CRISPR to find treatments for cancer and inflammation
Quick facts:
HQ: San Francisco, CA, United States
Fractional
Hiring
What they do:
The place where motivated investors and entrepreneurs co-own together.
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HQ: San Francisco, CA, United States
AstroForge
Hiring
What they do:
We Mine Asteroids
Quick facts:
HQ: Los Angeles, CA, United States
Posh
Hiring
What they do:
Rapidly deployable energy solutions for modern commercial and…
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HQ: San Francisco, CA, United States
What they do:
Bluedot is a single payment platform for EV drivers and fleets.
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HQ: San Francisco, CA, United States
Diffuse Bio
Hiring
What they do:
Generative AI for protein design
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HQ: San Francisco, CA, United States
Pax
Hiring
What they do:
AI Broker for Tariff Refunds
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HQ: San Francisco, CA, United States
Vendra
Hiring
What they do:
Custom Parts, Manufactured in America 🇺🇸
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HQ: San Francisco, CA, United States
Orbital Operations
Hiring
What they do:
High Thrust Space Vehicles for Satellite Defense
Quick facts:
HQ: Los Angeles, CA, United States
Proception Inc
Hiring
What they do:
Making humanoids dexterous enough to thread a needle
Quick facts:
HQ: San Francisco, CA, United States
Godela
Hiring
What they do:
AI Physics Engine to replace simulations and prototypes
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HQ: San Francisco, CA, United States
What they do:
We create activating antibodies to treat diseases others can’t.
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HQ: San Francisco, CA, United States
Hotplate
Hiring
What they do:
Online ordering platform for independent chefs and bakers.
Quick facts:
HQ: San Francisco, CA, United States
Vena Vitals
Hiring
What they do:
A small sticker that monitors blood pressure continuously
Quick facts:
HQ: Irvine, CA, United States
Text Blaze
Hiring
What they do:
Slash commands anywhere
Quick facts:
HQ: San Francisco, CA, United States
Airhart Aeronautics
Hiring
What they do:
Airplanes anyone can fly
Quick facts:
HQ: Los Angeles, CA, United States
Bild AI
Hiring
What they do:
AI estimating & detailing for Division 8 doors, frames & hardware
Quick facts:
HQ: San Francisco, CA, United States
Splash Inc.
Hiring
What they do:
Autonomous patrol-boats for National Security
Quick facts:
HQ: Los Angeles, CA, United States
What they do:
Upgraded helps retailers and carriers sell devices on subscription.
Quick facts:
HQ: San Francisco, CA, United States
Orangewood Labs
Hiring
What they do:
Orangewood builds amazing robots that people want
Quick facts:
HQ: San Francisco, CA, United States