What they do:
AI for the physical world
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HQ: San Francisco, CA, United States
Top Deep Tech Startups in California
This list has 846 startups and was last updated on Oct 15, 2026. 201 of them are hiring right now. Biggest hubs: San Francisco (704), Los Angeles (79), and San Diego (7). Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Circularity Fuels raised $8.79M (Oct 14, 2026).
846 startupsPage 12 of 24
What they do:
Truckload Planning at Machine Precision
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HQ: San Francisco, CA, United States
What they do:
AI-native real estate services firm
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HQ: Los Angeles, CA, United States
What they do:
Digital transformation for real economy businesses
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HQ: San Francisco, CA, United States
What they do:
Large-scale real-world robot & human data for embodied AI
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HQ: San Francisco, CA, United States
What they do:
Machine intelligence for American Welding
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HQ: Los Angeles, CA, United States
What they do:
Vanta for hardware
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HQ: San Francisco, CA, United States
What they do:
Autonomous operations for industrial distributors
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HQ: San Francisco, CA, United States
What they do:
Building the Data Infrastructure layer for Physical AI.
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HQ: San Francisco, CA, United States
What they do:
AI-native pharma company
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HQ: San Francisco, CA, United States
What they do:
The market behind AI hardware.
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HQ: San Francisco, CA, United States
What they do:
Building a neutral, sovereign alternative to Starlink
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HQ: San Francisco, CA, United States
What they do:
Making chemicals 100,000x faster
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HQ: San Francisco, CA, United States
What they do:
AI-native test infrastructure layer for hardware companies
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HQ: San Francisco, CA, United States
What they do:
Turns real businesses into robotics data vendors
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HQ: San Francisco, CA, United States
What they do:
Evals for robots
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HQ: San Francisco, CA, United States
What they do:
An AI-operated logistics company.
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HQ: San Francisco, CA, United States
What they do:
Embodied Scientific Intelligence
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HQ: San Francisco, CA, United States
What they do:
An AI bracelet that remembers your day and acts before you ask.
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HQ: San Francisco, CA, United States
What they do:
Motor cortex for physical AI
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HQ: San Francisco, CA, United States
What they do:
100% automated inspection for consumer electronics parts
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HQ: San Francisco, CA, United States
What they do:
Online circuit simulator and electronic schematic editor.
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HQ: San Francisco, CA, United States
What they do:
Fastest, easiest, and most affordable way for small business owners…
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HQ: San Francisco, CA, United States
What they do:
Synkrino's AI, SATIS is a powerful, unbiased discovery system for…
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HQ: San Francisco, CA, United States
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We put farms inside restaurants, so customers get healthier food and…
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HQ: San Francisco, CA, United States
What they do:
The Self-Hosting Company
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HQ: San Francisco, CA, United States
What they do:
Menten AI designs peptide and protein therapeutics using quantum…
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HQ: San Francisco, CA, United States
What they do:
Bioengineered kidneys for patients with kidney failure
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HQ: San Diego, CA, United States
What they do:
Neurostimulation implant to restore hearing & speech understanding
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HQ: San Francisco, CA, United States
What they do:
Build factory ready tech packs in minutes.
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HQ: Los Angeles, CA, United States
What they do:
Automated phone ordering system for restaurants
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HQ: San Francisco, CA, United States
What they do:
Growing seaweed to stabilize the climate.
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HQ: San Francisco, CA, United States
What they do:
Single source of truth for your clinic's finances and supply chain.
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HQ: San Francisco, CA, United States
What they do:
Automating nutrition tracking.
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HQ: San Francisco, CA, United States
What they do:
Building a frontier world model for power
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HQ: Los Angeles, CA, United States
What they do:
Genetically engineering plants for disease resistance.
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HQ: San Francisco, CA, United States